Evidence map›Paper›PMID 32823408›Full record

ArticleIndian journal of ophthalmology2020

Clinical manifestations and outcomes of ocular syphilis in Asian Indian population: Analysis of cases presenting to a tertiary referral center.

Mudit Tyagi, Hrishikesh Kaza, Avinash Pathengay, Hitesh Agrawal, Shashwat Behera, Dimple Lodha, Rajeev R Pappuru, Soumyava Basu, Somasheila Murthy

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Indian journal of ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Mudit TyagiSmt Kannuri Santhamma Center for Vitreoretinal Diseases, L V Prasad Eye Institute, KAR Campus, Hyderabad, Telangana, India.
Hrishikesh KazaVitreoretina and Uveitis Service, L V Prasad Eye Institute, GMRV Campus, Visakhapatnam, Andhra Pradesh, India.
Avinash PathengayVitreoretina and Uveitis Service, L V Prasad Eye Institute, GMRV Campus, Visakhapatnam, Andhra Pradesh, India.
Hitesh AgrawalSmt Kannuri Santhamma Center for Vitreoretinal Diseases, L V Prasad Eye Institute, KAR Campus, Hyderabad, Telangana, India.
Shashwat BeheraSmt Kannuri Santhamma Center for Vitreoretinal Diseases, L V Prasad Eye Institute, KAR Campus, Hyderabad, Telangana, India.
Dimple LodhaSmt Kannuri Santhamma Center for Vitreoretinal Diseases, L V Prasad Eye Institute, KAR Campus, Hyderabad, Telangana, India.
Rajeev R PappuruSmt Kannuri Santhamma Center for Vitreoretinal Diseases, L V Prasad Eye Institute, KAR Campus, Hyderabad, Telangana, India.
Soumyava BasuVitreoretina and Uveitis Service, L V Prasad Eye Institute, MTC Campus, Bhubaneswar, Odisha, India.
Somasheila MurthySmt Kannuri Santhamma Center for Vitreoretinal Diseases, L V Prasad Eye Institute, KAR Campus, Hyderabad, Telangana, India.
L V Prasad Eye Institute · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo describe disease manifestations and outcomes of ocular syphilis in Asian Indian population.

methodsRetrospective analysis of patients diagnosed with ocular syphilis at a tertiary referral center in India. Demographics, history, extraocular and ocular manifestations, ocular and systemic investigations, treatment and visual acuity outcomes were noted. All patients were diagnosed after necessary laboratory investigations including HIV ELISA (Human immunodeficiency virus, enzyme-linked immunosorbent assay), VDRL (venereal disease research laboratory), and TPHA (treponema pallidum hemagglutination).

resultsTotally, 20 patients with mean age at presentation 38.25 ± 9.76 were analyzed. 9/20 patients had bilateral involvement. 8/20 had concurrent HIV at presentation with an average CD4 counts of 592.25 ± 411.34 cells/microliter. The mean duration of symptoms at time of presentation was 15.45 ± 35.15 weeks. VDRL test was reactive in 45% (9/20) patients whereas, all patients had a reactive TPHA test. Clinical manifestations included outer retinal placoid chorioretinitis lesions (8/20, 40%), followed by retinitis mimicking acute retinal necrosis as the second most common phenotype (4/20, 20%). Other presenting manifestations noted were panuveitis, miliary retinitis lesions, retinal vasculitis, intermediate uveitis, and anterior uveitis. The clinical phenotypes in immunocompromised included panuveitis, acute retinal necrosis and isolated anterior uveitis. Mean follow up duration was 6.32 ± 6.15 months. An improvement in mean best corrected visual acuity (BCVA) of (0.63 LogMAR, approximately 6 Snellen lines, P < 0.02) was noted at last follow-up.

conclusionPhenotypic manifestations of ocular syphilis are varied. Non-treponemal tests like VDRL may be unreliable when compared with treponemal tests in diagnosing ocular syphilis. Syphilitic uveitis is considered equivalent to neurosyphilis and is treated similar to neurosyphilis.

Indexed as

Eye Infections, BacterialSyphilisHumansIndiaRetrospective StudiesTertiary Care CentersHIVlueticocular syphilispanuveitis and granulomatoussyphilis

Identifiers

PMID32823408
PMCPMC7690535
OpenAlexW3080915937

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.