Evidence map›Paper›PMID 32823395›Full record

ReviewIndian journal of ophthalmology2020

Human immunodeficiency virus and intraocular inflammation in the era of highly active anti retroviral therapy - An update.

Sridharan Sudharshan, Nivedita Nair, Andre Curi, Alay Banker, John H Kempen

Open access · diamondAbstract readReview
In one paragraph

Review in Indian journal of ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Association between human immunodeficiency virus infection and the risk of glaucoma: a real-world multicenter cohort study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  2. Article
  3. Article
  4. Prevalence of uveitis in syphilis patients in Taiwan.Emerging microbes & infections · 2024
    Article
  5. Immune recovery uveitis: a focus review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024
    Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Ocular manifestations of people living with HIV in Tunisia.Southern African journal of HIV medicine · 2021
    Article
  13. Exploring a New Era in Uveitis.Indian journal of ophthalmology · 2020
    Article
  14. Immune Privilege: The Microbiome and Uveitis.Frontiers in immunology · 2020
    Review
  15. Article
  16. Keratitis patterns in patients with human immunodeficiency virus: A 10-year retrospective study.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Sridharan SudharshanDepartment of Uveitis, Medical Research Foundation, Chennai, Tamil Nadu, India.
Nivedita NairDepartment of Uveitis, Medical Research Foundation, Chennai, Tamil Nadu, India.
Andre CuriAndré Luiz Land Curi, National Institute of Infectious Diseases - INI/ Fiocruz; Clinical Research Laboratory of Infectious, Diseases in Ophthalmology - INI / Fiocruz, Brazil.
Alay BankerBanker's Retina Clinic and Laser Centre, Ahmedabad, Gujarat, India.
John H KempenDepartment of Ophthalmology, Massachusetts Eye and Ear and Harvard Medical School; Schepens Eye Research Institute, Boston, Massachusetts, USA; MCM Eye Unit, MyungSung Christian Medical Center (MCM) General Hospital and MyungSung Medical College, Addis Ababa, Ethiopia.
Smith-Kettlewell Eye Research Institute · USInstitute of Integrated Clinical Research (Brazil) · BRMassachusetts Eye and Ear Infirmary · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intraocular inflammation in patients with human immunodeficiency virus (HIV) infection is commonly due to infectious uveitis. Ocular lesions due to opportunistic infections (OI) are the most common and have been described extensively in the pre highly active antiretroviral therapy (HAART) era. Many eye lesions were classified as acquired immunodeficiency syndrome (AIDS) defining illnesses. HAART-associated improvement in immunity of the individual has changed the pattern of incidence of these hitherto reported known lesions leading to a marked reduction in the occurrence of ocular OI. Newer ocular lesions and newer ocular manifestations of known agents have been noted. Immune recovery uveitis (IRU), the new menace, which occurs as part of immune recovery inflammatory syndrome (IRIS) in the eye, can present with significant ocular inflammation and can pose a diagnostic and therapeutic challenge. Balancing the treatment of inflammation with the risk of reactivation of OI is a task by itself. Ocular involvement in the HAART era can be due to the adverse effects of some systemic drugs used in the management of HIV/AIDS. Drug-associated retinal toxicity and other ocular side effects are being increasingly reported. In this review, we discuss the ocular manifestations in HIV patients and its varied presentations following the introduction of HAART, drug-associated lesions, and the current treatment guidelines.

Indexed as

AIDS-Related Opportunistic InfectionsCytomegalovirus RetinitisHIV InfectionsUveitisAntiretroviral Therapy, Highly ActiveHIVHumansInflammationAIDSCMV retinitisdrug-induced uveitisHAARTherpes zosterHIVintraocular inflammationIRUocular opportunistic infectionsocular syphilisocular TBocular toxoplasmosisretinopathyuveitis

Identifiers

PMID32823395
PMCPMC7690468
OpenAlexW3080511278

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.