ArticleNeurobiology of learning and memory2020
Amnesia for context fear is caused by widespread disruption of hippocampal activity.
Article in Neurobiology of learning and memory, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 42 citations in OpenAlex.
- Ventral hippocampus mediates inter-trial responding in signaled active avoidance.Behavioural brain research · 2024Article
- Prefrontal coding of learned and inferred knowledge during REM and NREM sleep.Nature communications · 2024Article
- Article
- Ventral hippocampus mediates inter-trial responding in signaled active avoidance.bioRxiv : the preprint server for biology · 2024Article
- Effects of theta phase precessing optogenetic intervention on hippocampal neuronal reactivation and spatial maps.iScience · 2023Article
- Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine.Nature neuroscience · 2022Article
- A novel role for the lateral habenula in fear learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- The spatiotemporal organization of experience dictates hippocampal involvement in primary visual cortical plasticity.Current biology : CB · 2021Article
- High-Frequency Stimulation of Ventral CA1 Neurons Reduces Amygdala Activity and Inhibits Fear.Frontiers in behavioral neuroscience · 2021Article
- Article
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8 authors at 1 institution in 1 country.
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Abstract
The hippocampus plays an essential role in the formation and retrieval of episodic memories in humans and contextual memories in animals. However, amnesia is not always observed when this structure is compromised. To determine why this is the case, we compared the effects of several different circuit manipulations on memory retrieval and hippocampal activity. Mice were first trained on context fear conditioning and then optogenetic and chemogenetic tools were used to alter activity during memory retrieval. We found that retrieval was only impaired when manipulations caused widespread changes (increases or decreases) in hippocampal activity. Widespread increases occurred when pyramidal cells were excited and widespread decreases were found when GABAergic neurons were stimulated. Direct hyperpolarization of excitatory neurons only moderately reduced activity and did not produce amnesia. Surprisingly, widespread decreases in hippocampal activity did not prevent retrieval if they occurred gradually prior to testing. This suggests that intact brain regions can express contextual memories if they are given adequate time to compensate for the loss of the hippocampus.
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