Evidence map›Paper›PMID 32822840›Full record

ReviewTrends in cardiovascular medicine2021

Experimental limitations of extracellular vesicle-based therapies for the treatment of myocardial infarction.

Tahnee L Kennedy, Angela J Russell, Paul Riley

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Tahnee L KennedyDepartment of Physiology, Anatomy & Genetics, University of Oxford. Sherrington Building, South Parks Road, Oxford OX1 3PT, United Kingdom.
Angela J RussellDepartment of Chemistry, University of Oxford. Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, United Kingdom; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom.
Paul RileyDepartment of Physiology, Anatomy & Genetics, University of Oxford. Sherrington Building, South Parks Road, Oxford OX1 3PT, United Kingdom. Electronic address: paul.riley@dpag.ox.ac.uk.

Funding

British Heart Foundation CH/11/1/28798British Heart Foundation RM/17/2/33380
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are particles secreted by a vast variety of cells and are often recognised to mimic the properties of their parent cell, as such those derived from developmental sources hold promise for the treatment of various diseases including myocardial infarction (MI). Here we review the experimental approaches taken for assessing the therapeutic efficacy of EVs for MI and find overt shortcomings regarding purity of isolated EVs, quantitation, dosing, EV labelling/uptake, route of administration and use of appropriate controls that renders much of the data uninterpretable. Overall, the EV/MI field has suffered from experimental approaches that are not fully standardised or validated. Fundamental improvements in EV study design are required to improve interpretation of efficacy and to ensure reproducibility and comparability across preclinical MI studies.

Indexed as

Extracellular VesiclesMyocardial InfarctionHumansReproducibility of ResultsCharacterisationdosing and uptakeExtracellular vesiclesIsolationMode-of-actionMyocardial infarctionPreclinical studies

Identifiers

PMID32822840
PMCPMC8501308

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.