Evidence map›Paper›PMID 32822728›Full record

ReviewBiochimica et biophysica acta. Molecular cell research2020

Fe-S cluster biogenesis by the bacterial Suf pathway.

Matthew Blahut, Enis Sanchez, Claire E Fisher, F Wayne Outten

Open access · greenAbstract readReview
In one paragraph

Review in Biochimica et biophysica acta. Molecular cell research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 92 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Biogenic Selenium Nanoparticles from Food-GradeFoods (Basel, Switzerland) · 2026
    Article
  6. Article
  7. The structure of the SufBCbioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Protein-centric mechanisms of typhoidalFrontiers in cellular and infection microbiology · 2026
    Review
  13. Article
  14. SmsB-SmsC machinery inApplied and environmental microbiology · 2025
    Article
  15. Article
  16. Article
  17. Transcriptome-Proteome Profiling inJournal of proteome research · 2025
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Matthew BlahutDepartment of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, SC 29208, USA.
Enis SanchezDepartment of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, SC 29208, USA.
Claire E FisherDepartment of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, SC 29208, USA.
F Wayne OuttenDepartment of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, SC 29208, USA. Electronic address: woutten@sc.edu.
University of South Carolina Sumter · US

Funding

Conformational dynamics and allosteric regulation during stress-responsive metallocofactor assemblyR01GM112919 · NIGMS · UNIVERSITY OF ALABAMA IN TUSCALOOSA · PI Patrick Frantom · 2015 to 2026
$2.8M
NIGMS NIH HHS R01 GM112919
6 · The paper itself

Abstract

Biogenesis of iron-sulfur (FeS) clusters in an essential process in living organisms due to the critical role of FeS cluster proteins in myriad cell functions. During biogenesis of FeS clusters, multi-protein complexes are used to drive the mobilization and protection of reactive sulfur and iron intermediates, regulate assembly of various FeS clusters on an ATPase-dependent, multi-protein scaffold, and target nascent clusters to their downstream protein targets. The evolutionarily ancient sulfur formation (Suf) pathway for FeS cluster assembly is found in bacteria and archaea. In Escherichia coli, the Suf pathway functions as an emergency pathway under conditions of iron limitation or oxidative stress. In other pathogenic bacteria, such as Mycobacterium tuberculosis and Enterococcus faecalis, the Suf pathway is the sole source for FeS clusters and therefore is a potential target for the development of novel antibacterial compounds. Here we summarize the considerable progress that has been made in characterizing the first step of mobilization and protection of reactive sulfur carried out by the SufS-SufE or SufS-SufU complex, FeS cluster assembly on SufBC

Indexed as

Evolution, MolecularAdenosine TriphosphatasesEnterococcus faecalisEscherichia coliEscherichia coli ProteinsIronIron-Sulfur ProteinsLyasesMetabolic Networks and PathwaysMultigene FamilyMycobacterium tuberculosisSulfurAdenosine TriphosphatasesEscherichia coli ProteinsIronIron-Sulfur ProteinsLyasesselenocysteine lyaseSufC protein, E coliSufD protein, E coliSuf E protein, E coliSulfurA-type carrier proteinIronIron-sulfur clusterMetallocofactorSuf

Identifiers

PMID32822728
PMCPMC7510350
OpenAlexW3070123615

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.