ArticleCurrent biology : CB2020
Subanesthetic Ketamine Reactivates Adult Cortical Plasticity to Restore Vision from Amblyopia.
Article in Current biology : CB, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 61 citations in OpenAlex.
- Towards a neurobiology of early intervention: the importance of critical periods for preventive psychiatry and youth mental health.Molecular psychiatry · 2026Review
- The Emerging Neurobiology of Psychedelics: Critical Periods, Metaplasticity, and Extracellular Matrix Remodeling.Annual review of neuroscience · 2026Review
- Ibogaine induces juvenile-like plasticity and modulates functional and structural regulators of plasticity in the adult mouse visual cortex.BMC neuroscience · 2026Article
- Learning as the unifying mechanism of psychedelic action.Journal of psychopharmacology (Oxford, England) · 2026Review
- The science of psychedelic medicine.Nature medicine · 2026Review
- Review
- An AAV capsid proposed as microglia-targeting directs genetic expression in forebrain excitatory neurons.Cell reports methods · 2025Article
- A Systematic Review and Meta-Analysis of Perceptual Learning and Video Game Training for Adults with Monocular Amblyopia.Ophthalmology and therapy · 2025Review
- Time-dependent biphasic alterations in brain metabolism following chronic ketamine exposure in mice.Frontiers in pharmacology · 2025Article
- Interactions between excitatory neurons and parvalbumin interneurons in V1 underlie neural mechanisms of amblyopia and visual stimulation treatment.Communications biology · 2024Article
- The relationship between visual acuity loss and GABAergic inhibition in amblyopia.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Article
- Anatomical and molecular characterization of parvalbumin-cholecystokinin co-expressing inhibitory interneurons: implications for neuropsychiatric conditions.Molecular psychiatry · 2023Article
- Erythrocyte-brain endothelial interactions induce microglial responses and cerebral microhemorrhages in vivo.Journal of neuroinflammation · 2023Article
- Structural and functional alterations in the brains of patients with anisometropic and strabismic amblyopia: a systematic review of magnetic resonance imaging studies.Neural regeneration research · 2023Article
- Psychedelics promote plasticity by directly binding to BDNF receptor TrkB.Nature neuroscience · 2023Article
- Article
- The laterodorsal tegmentum-ventral tegmental area circuit controls depression-like behaviors by activating ErbB4 in DA neurons.Molecular psychiatry · 2023Article
- Human deprivation amblyopia: treatment insights from animal models.Frontiers in neuroscience · 2023Article
- Psychedelics and Neural Plasticity: Therapeutic Implications.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Subanesthetic ketamine evokes rapid and long-lasting antidepressant effects in human patients. The mechanism for ketamine's effects remains elusive, but ketamine may broadly modulate brain plasticity processes. We show that single-dose ketamine reactivates adult mouse visual cortical plasticity and promotes functional recovery of visual acuity defects from amblyopia. Ketamine specifically induces downregulation of neuregulin-1 (NRG1) expression in parvalbumin-expressing (PV) inhibitory neurons in mouse visual cortex. NRG1 downregulation in PV neurons co-tracks both the fast onset and sustained decreases in synaptic inhibition to excitatory neurons, along with reduced synaptic excitation to PV neurons in vitro and in vivo following a single ketamine treatment. These effects are blocked by exogenous NRG1 as well as PV targeted receptor knockout. Thus, ketamine reactivation of adult visual cortical plasticity is mediated through rapid and sustained cortical disinhibition via downregulation of PV-specific NRG1 signaling. Our findings reveal the neural plasticity-based mechanism for ketamine-mediated functional recovery from adult amblyopia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.