Evidence map›Paper›PMID 32822540›Full record

ArticleThe British journal of radiology2020

Stereotactic body radiotherapy for adrenal oligometastasis in lung cancer patients.

Fabio Arcidiacono, Cynthia Aristei, Alessandro Marchionni, Marco Italiani, Cristian Paolo Luca Fulcheri, Simonetta Saldi, Michelina Casale, Gianluca Ingrosso, Paola Anselmo, Ernesto Maranzano

2 registry-linked trialsOpen access · greenAbstract read
In one paragraph

Article in The British journal of radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05291780 nacompletednot on this map

STereotactic Ablative RadioTherapy in NEWly Diagnosed and Recurrent Locally Advanced Non-small Cell Lung Canter Patients Unfit for concurrEnt RAdio-chemotherapy

TypeinterventionalSponsorRadiotherapy Oncology Centre "Santa Maria" HospitalRan2015 to 2021Enrolled80ConditionsLocally Advanced Lung Non-Small Cell CarcinomaArmsStereotactic Ablative Radiotherapy in Unresectable Locally Advanced Non-Small Cell Lung Cancer
NCT06207292 naunknown statusnot on this map

STereotactic Ablative RadioTherapy in NEWly Synchronous and mEtachRonous (Oligo-persistence, Oligo-induced, Oligo-progression) Oncogene and Non Oncogene Addicted OLIGO-metastatic Non-small Cell Lung Cancer Patients

TypeinterventionalSponsorRadiotherapy Oncology Centre "Santa Maria" HospitalRan2016 to 2024Enrolled100ConditionsNSCLC, NSCLC Stage IV, Oligometastatic Disease, Non Small Cell Lung CancerArmsStereotactic Ablative Radiotherapy
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  12. Stereotactic radiotherapy for adrenal oligometastases.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2022
    Review
  13. Article
  14. Article
  15. ADVANCES IN RADIOTHERAPY OF ADRENAL GLAND LESIONS.Acta endocrinologica (Bucharest, Romania : 2005)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Fabio ArcidiaconoRadiotherapy Oncology Centre, "S. Maria" Hospital, Terni, Italy.
Cynthia AristeiDepartment of Surgical and Biomedical Science, Radiotherapy Oncology Centre, University of Perugia and "Santa Maria della Misericordia" Hospital, Perugia, Italy.
Alessandro MarchionniDepartment of Surgical and Biomedical Science, Radiotherapy Oncology Centre, University of Perugia and "Santa Maria della Misericordia" Hospital, Perugia, Italy.
Marco ItalianiRadiotherapy Oncology Centre, "S. Maria" Hospital, Terni, Italy.
Cristian Paolo Luca FulcheriRadiotherapy Oncology Centre, "Santa Maria della Misericordia" Hospital, Perugia, Italy.
Simonetta SaldiRadiotherapy Oncology Centre, "Santa Maria della Misericordia" Hospital, Perugia, Italy.
Michelina CasaleRadiotherapy Oncology Centre, "S. Maria" Hospital, Terni, Italy.
Gianluca IngrossoDepartment of Surgical and Biomedical Science, Radiotherapy Oncology Centre, University of Perugia and "Santa Maria della Misericordia" Hospital, Perugia, Italy.
Paola AnselmoRadiotherapy Oncology Centre, "S. Maria" Hospital, Terni, Italy.
Ernesto MaranzanoRadiotherapy Oncology Centre, "S. Maria" Hospital, Terni, Italy.ORCID http://orcid.org/0000-0003-4249-4064
Santa Maria Nuova Hospital · ITUniversity of Perugia · ITAzienda Ospedaliera di Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo report our experience on stereotactic body radiotherapy (SBRT) in adrenal metastases from lung cancer.

methods37 oligometastatic lung cancer patients with 38 adrenal metastases submitted to SBRT were retrospectively analyzed. SBRT was delivered by volumetric modulated arc therapy (VMAT) or helical tomotherapy (HT). Primary study end point was local recurrence-free survival (LR-FS) and secondary end points were distant-progression free survival (d-PFS) and overall survival (OS).

resultsMedian age was 67 years and primary tumor was non-small-cell lung cancer in 27 (73%) and small-cell lung cancer in 10 (27%) patients. Adrenal metastases were in the left side in 66% cases. Median prescribed dose was 30 Gy in 5 fractions for a median biologically equivalent dose (α/β ratio 10  Gy, BED10) of 48 Gy. Most patients (62%) were submitted to SBRT alone, while the others (38%) received chemo-, immune- or target- therapies. Median follow-up was 10.5 months, median OS 16 months and median d-PFS 3 months. 27 (70%) patients obtained a local control with a median LR-FS of 32 months. LR-FS was significantly related to BED10 with a better LC with BED10 ≥72 Gy, 1- and 2 year LR-FS rates were 54.1±11.6% and 45±12.7%

conclusionSBRT was effective and safe in lung cancer adrenal metastases. A dose-response relationship was found between BED10 ADVANCES IN KNOWLEDGE: SBRT with a BED10

Indexed as

Adrenal Gland NeoplasmsAdultAgedAged, 80 and overCarcinoma, Non-Small-Cell LungCombined Modality TherapyDose Fractionation, RadiationDose-Response Relationship, RadiationFemaleHumansLung NeoplasmsMaleMiddle AgedProgression-Free SurvivalRadiosurgeryRadiotherapy, Intensity-Modulated

Identifiers

PMID32822540
PMCPMC8519655
OpenAlexW3081282756

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.