ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2021
Measuring Exercise Capacity and Physical Function in Adult and Older Mice.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Exploring In Vivo Models of Musculoskeletal Frailty: A Comprehensive Systematic Review.International journal of molecular sciences · 2023Pooled it
- High-intensity interval training in aged female mice preserves physical, cognitive, and cardiovascular function.GeroScience · 2026Article
- A bacterial enzyme enhances both energy metabolism and health across the life span ofScience advances · 2026Article
- Constitutive mTORC1 activation in skeletal muscle increases inflammation but is not sufficient to impair glucose tolerance.Function (Oxford, England) · 2026Article
- Corylin promotes healthy aging via RAGA-mTOR suppression and sex-dependent activation of SIRT3.Nature communications · 2026Article
- Hyperactive muscle mTORC1 attenuates functional adaptations to endurance training despite alterations in mitochondrial and lipid profiles.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Provocative testing in community dwelling older adults: a path to identify physical resilience.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Effects of Nicotinamide Mononucleotide Supplementation and Aerobic Exercise on Metabolic Health and Physical Performance in Aged Mice.Nutrients · 2025Article
- Article
- Aerobic Exercise Delays Age-Related Sarcopenia in Mice via Alleviating Imbalance in Mitochondrial Quality Control.Metabolites · 2025Article
- Low-frequency ultrasound reverses insulin resistance and diabetes-induced changes in the muscle transcriptome in aged mice.American journal of physiology. Endocrinology and metabolism · 2025Article
- Nicotinamide riboside alleviates ionizing radiation-induced intestinal senescence by alleviating oxidative damage and regulating intestinal metabolism.Journal of advanced research · 2025Article
- Effects of 3-(4-Hydroxy-3-methoxyphenyl)propionic Acid on Regulating Oxidative Stress and Muscle Fiber Composition.Nutrients · 2025Article
- Longitudinal Decline of Exercise Capacity in Male and Female Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Effects of high-intensity interval training on physical and cognitive function in middle-aged male mice.Frontiers in aging · 2025Article
- Relationship between physical function and sarcopenia in the older adults from Amazonas: A cross-sectional study.PloS one · 2025Article
- Wild capuchin monkeys as a model system for investigating the social and ecological determinants of ageing.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Decoding the decline: unveiling drivers of sarcopenia.The Journal of clinical investigation · 2024Article
- Longitudinal Decline of Exercise Capacity in Male and Female Mice.bioRxiv : the preprint server for biology · 2024Article
- Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The inability of older adults to maintain independence is a consequence of sarcopenia and frailty. In order to identify the molecular mechanisms responsible for decreased physical function, it will be critical to utilize a small animal model. The main purpose of this study was to develop a composite Comprehensive Functional Assessment Battery (CFAB) of well-validated tests to determine physical function and exercise capacity in 3 age groups of male C57BL/6 mice (6 months old, n = 29; 24 months old, n = 24; 28+ months old, n = 28). To measure physical function in mice, we used rotarod (overall motor function), grip meter (forelimb strength), treadmill (endurance), inverted cling (strength/endurance), voluntary wheel running (volitional exercise and activity rate), and muscle performance with in vivo contractile physiology (dorsiflexor torque). We hypothesized that CFAB would be a valid means to assess the physical function of a given mouse across the life span. In addition, we proposed that CFAB could be used to determine relationships between different parameters associated with sarcopenia. We found that there was an overall age-related significant decline (p < .05) in all measurements, and the CFAB score demonstrated that some individual mice (the upper quartile) retained the functional capacity of average mice 1 cohort younger. We conclude that the CFAB is a powerful, repeatable, and noninvasive tool to assess and compare physical function and assess complex motor task ability in mice, which will enable researchers to easily track performance at the individual mouse level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.