Evidence map›Paper›PMID 32822344›Full record

ArticlePloS one2020

Genotoxic effect of 2,2'-bis(bicyclo[2.2.1] heptane) on bacterial cells.

A Kessenikh, E Gnuchikh, S Bazhenov, M Bermeshev, V Pevgov, V Samoilov, S Shorunov, A Maksimov, L Yaguzhinsky, I Manukhov

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Thermally InducedMicroorganisms · 2026
    Article
  2. RSC advances · 2024
    Article
  3. Heliyon · 2023
    Article
  4. Article
  5. Article
  6. Constructing ofInternational journal of molecular sciences · 2021
    Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

A KessenikhMoscow Institute of Physics and Technology, Dolgoprudny, Moscow, Russia.
E GnuchikhMoscow Institute of Physics and Technology, Dolgoprudny, Moscow, Russia.
S BazhenovMoscow Institute of Physics and Technology, Dolgoprudny, Moscow, Russia.
M BermeshevTopchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow, Russia.
V PevgovMoscow Institute of Physics and Technology, Dolgoprudny, Moscow, Russia.
V SamoilovTopchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow, Russia.
S ShorunovTopchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow, Russia.
A MaksimovTopchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow, Russia.
L YaguzhinskyMoscow Institute of Physics and Technology, Dolgoprudny, Moscow, Russia.
I ManukhovMoscow Institute of Physics and Technology, Dolgoprudny, Moscow, Russia.ORCID 0000-0001-8646-7207
Moscow Institute of Physics and Technology · RURussian Academy of Sciences · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The toxic effect of strained hydrocarbon 2,2'-bis (bicyclo[2.2.1]heptane) (BBH) was studied using whole-cell bacterial lux-biosensors based on Escherichia coli cells in which luciferase genes are transcriptionally fused with stress-inducible promoters. It was shown that BBH has the genotoxic effect causing bacterial SOS response however no alkylating effect has been revealed. In addition to DNA damage, there is an oxidative effect causing the response of OxyR/S and SoxR/S regulons. The most sensitive to BBH lux-biosensor was E. coli pSoxS-lux which reacts to the appearance of superoxide anion radicals in the cell. It is assumed that the oxidation of BBH leads to the generation of reactive oxygen species, which provide the main contribution to the genotoxicity of this substance.

Indexed as

AlkylationBiosensing TechniquesBridged Bicyclo CompoundsDNA DamageDose-Response Relationship, DrugEscherichia coliMutagensOxidative StressRegulonbicyclo(2.2.1)hepteneBridged Bicyclo CompoundsMutagens

Identifiers

PMID32822344
PMCPMC7444485
OpenAlexW3081424527

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.