Evidence map›Paper›PMID 32822209›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2020

p38δ genetic ablation protects female mice from anthracycline cardiotoxicity.

Sharon A George, Alexi Kiss, Sofian N Obaid, Aileen Venegas, Trisha Talapatra, Chapman Wei, Tatiana Efimova, Igor R Efimov

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. RNAi-mediated p38δ silencing mitigates anthracycline cardiotoxicity in female mice.American journal of physiology. Heart and circulatory physiology · 2026
    Article
  4. Review
  5. CoordinatedeLife · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sharon A GeorgeDepartment of Biomedical Engineering, The George Washington University, Washington, District of Columbia.
Alexi KissDepartment of Anatomy and Cell Biology, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.
Sofian N ObaidDepartment of Biomedical Engineering, The George Washington University, Washington, District of Columbia.
Aileen VenegasDepartment of Biomedical Engineering, The George Washington University, Washington, District of Columbia.
Trisha TalapatraDepartment of Biomedical Engineering, The George Washington University, Washington, District of Columbia.
Chapman WeiDepartment of Anatomy and Cell Biology, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.ORCID 0000-0002-2004-5412
Tatiana EfimovaDepartment of Anatomy and Cell Biology, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.
Igor R EfimovDepartment of Biomedical Engineering, The George Washington University, Washington, District of Columbia.ORCID 0000-0002-1483-5039
George Washington University · US

Funding

American Heart Association-American Stroke Association 19POST34370122
6 · The paper itself

Abstract

The efficacy of an anthracycline antibiotic doxorubicin (DOX) as a chemotherapeutic agent is limited by dose-dependent cardiotoxicity. DOX is associated with activation of intracellular stress signaling pathways including p38 MAPKs. While previous studies have implicated p38 MAPK signaling in DOX-induced cardiac injury, the roles of the individual p38 isoforms, specifically, of the alternative isoforms p38γ and p38δ, remain uncharacterized. We aimed to determine the potential cardioprotective effects of p38γ and p38δ genetic deletion in mice subjected to acute DOX treatment. Male and female wild-type (WT), p38γ

Indexed as

DoxorubicinAnimalsAutophagyCardiotoxicityDisease Models, AnimalFemaleFibrosisGene Knockout TechniquesHeart DiseasesMaleMice, Inbred C57BLMice, KnockoutMicrotubule-Associated ProteinsMitogen-Activated Protein Kinase 12Mitogen-Activated Protein Kinase 13MyocardiumDoxorubicinMap1lc3b protein, mouseMicrotubule-Associated ProteinsMitogen-Activated Protein Kinase 12Mitogen-Activated Protein Kinase 13mTOR protein, mouseTOR Serine-Threonine Kinasescardioprotectiondoxorubicinp38 MAPKp38δ/MAPK13sex differences

Identifiers

PMID32822209
PMCPMC11018268
OpenAlexW3080555159

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.