Evidence map›Paper›PMID 32822081›Full record

ArticleJournal of the American Geriatrics Society2020

Co-Occurrence of Lower Urinary Tract Symptoms and Frailty among Community-Dwelling Older Men.

Scott R Bauer, Rebecca Scherzer, Anne M Suskind, Peggy Cawthon, Kristine E Ensrud, William A Ricke, Kenneth Covinsky, Lynn M Marshall, Osteoporotic Fractures in Men (MrOS) Research Group

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 38 citations in OpenAlex.

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  7. Underactive bladder as defined by the International Continence Society in the 2023 Japan Community Health Survey.International journal of urology : official journal of the Japanese Urological Association · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Scott R BauerDepartment of Medicine, University of California, San Francisco, California, USA.ORCID 0000-0003-4908-1924
Rebecca ScherzerVeterans Affairs Medical Center, San Francisco, California, USA.
Anne M SuskindDepartment of Urology, University of California, San Francisco, California, USA.
Peggy CawthonResearch Institute, California Pacific Medical Center, San Francisco, California, USA.ORCID 0000-0003-4938-9478
Kristine E EnsrudDivision of Epidemiology and Community Health, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-9069-3036
William A RickeDepartment of Urology, George M. O'Brien Center of Research Excellence, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Kenneth CovinskyDepartment of Medicine, University of California, San Francisco, California, USA.
Lynn M MarshallDepartment of Orthopaedics and Rehabilitation, Oregon Health and Science University, Portland, Oregon, USA.
Osteoporotic Fractures in Men (MrOS) Research Group
San Francisco VA Medical Center · USCalifornia Pacific Medical Center · USPortland State University · USUniversity of California, San Francisco · USUniversity of Minnesota · USUniversity of Wisconsin–Madison · US

Funding

Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
Oregon Clinical and Translational Research InstituteUL1TR000128 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLISON, DAVID H · 2012 to 2015
$28.7M
VARC CoreP30AG044281 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alexander Keliimoeanu Smith · 2013 to 2026
$19.9M
Long term fracture risk and change in peripheral bone in the oldest old men: The MrOS studyR01AG066671 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI BOUXSEIN, MARY L, CAWTHON, PEGGY MANNEN · 2020 to 2024
$13.3M
Role of Beta-Catenin in Urinary DysfunctionU54DK104310 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI BJORLING, DALE EDMOND · 2014 to 2023
$12.8M
OSTEOPOROTIC FRACTURES IN MENU01AG018197 · NIA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI CUMMINGS, STEVEN RON · 1999 to 2011
$12.7M
Osteoporotic Fractures in Men: MrOS Renewal-PortlandU01AR045647 · NIAMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 1999 to 2011
$6.7M
UCSF-Kaiser Urological Epidemiology Research Career Development ProgramK12DK111028 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, ALISON · 2016 to 2025
$5.3M
Osteoporotic Fractures in Men (MrOS) - MinneapolisU01AG042145 · NIA · UNIVERSITY OF MINNESOTA · PI ENSRUD, KRISTINE · 2013 to 2019
$5.3M
Osteporotic Fractures in Men (MrOS)- Admin CenterU01AG027810 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2006 to 2017
$5.1M
Osteoporotic Fractures in Men - Renewal: PittsburghU01AR045654 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAULEY, JANE ANN · 1999 to 2011
$5.1M
OSTEOPOROTIC FRACTURES IN MENU01AR045614 · NIAMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ENSRUD, KRISTINE · 1999 to 2011
$4.0M
NCATS NIH HHS UL1 TR000128NCATS NIH HHS UL1 TR002369NIAMS NIH HHS U01 AR045580NIAMS NIH HHS U01 AR045583NIAMS NIH HHS U01 AR045614NIAMS NIH HHS U01 AR045632NIAMS NIH HHS U01 AR045647NIAMS NIH HHS U01 AR045654NIAMS NIH HHS U01 AR45580NIAMS NIH HHS U01 AR45583NIAMS NIH HHS U01 AR45614NIAMS NIH HHS U01 AR45632NIAMS NIH HHS U01 AR45647NIAMS NIH HHS U01 AR45654NIA NIH HHS P30 AG044281NIA NIH HHS R01 AG066671NIA NIH HHS R03 AG067937NIA NIH HHS R56 AG061085NIA NIH HHS U01 AG018197NIA NIH HHS U01 AG027810NIA NIH HHS U01 AG042145NIDDK NIH HHS 1K12DK111028NIDDK NIH HHS K12 DK111028NIDDK NIH HHS U54 DK104310NIH HHS U01 AG18197NIH HHS U54 104310
6 · The paper itself

Abstract

BACKGROUND/

objectivesTo estimate associations between lower urinary tract symptoms (LUTS) and phenotypic frailty in older men.

designCross-sectional study.

settingCommunity-dwelling men recruited from 2000 to 2002 from six U.S. academic centers for the Osteoporotic Fractures in Men Study.

participantsA total of 5,979 men aged 65 and older. MEASUREMENTS: The independent variable was LUTS severity (none/mild, moderate, or severe) assessed with the American Urologic Association Symptom Index. Participants were categorized as frail, intermediate stage, or robust using an adapted Cardiovascular Health Study index (components: low lean mass, weakness, exhaustion, slowness, and low physical activity). Associations were estimated with odds ratios and 95% confidence intervals (CIs) from multivariable multinomial logistic regression models adjusted for potential confounders of age, other demographics, health-related behaviors, and comorbidities.

resultsThe prevalence of frailty was 7%, 11%, and 18% among men with none/mild, moderate, and severe LUTS, respectively. Moderate and severe LUTS, overall and by storage and voiding subscores, were associated with higher odds of both intermediate stage and frailty in all models. After adjustment for confounders, the odds of frailty was 1.41 times higher among men with moderate LUTS (95% CI = 1.14-1.74) and 2.51 times higher among men with severe LUTS (95% CI = 1.76-3.55), compared with none/mild LUTS. Severe LUTS was associated with a greater odds of individual frailty components exhaustion and low physical activity.

conclusionThe prevalence of phenotypic frailty is higher among older community-dwelling men with moderate or severe LUTS compared with those with mild or no LUTS. The positive association between LUTS severity and frailty among older men appears independent of age and known frailty risk factors. Although the temporal direction of this association and the utility of LUTS or frailty interventions in this population remain unclear, the high co-occurrence of these conditions could lead to earlier identification of frailty when clinically appropriate.

Indexed as

ComorbidityIndependent LivingUrinary IncontinenceAgedAge FactorsCross-Sectional StudiesFrailtyHumansLower Urinary Tract SymptomsMalePrevalenceRisk FactorsSurveys and QuestionnairesUnited Statesfrailtygeriatric syndrome (1-5 Medical Subject Headings)lower urinary tract symptomsurinary incontinence

Identifiers

PMID32822081
PMCPMC7744321
OpenAlexW3080113240

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.