ReviewBurns & trauma2020
Microbiome in the setting of burn patients: implications for infections and clinical outcomes.
Review in Burns & trauma, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07209007 (An Exploratory Study on the Dynamics of Microbiome Dysbiosis), which is not on this map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Exploratory Study on the Dynamics of Microbiome Dysbiosis (Microbial Imbalance) in the Skin and Gut Microbiome of Burn Patients
Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
- Microbiome Profiling and Antimicrobial Efficacy of a Novel Silver-Nanoparticle Hydrogel Dressing Against Clinical Isolates From Paediatric Burn Wounds.MicrobiologyOpen · 2026Article
- The dual role of the microbiome in chronic wound management.Cell communication and signaling : CCS · 2026Review
- Drug-Resistant Infections in Burn Patients: A One-Year Analysis of Microbiological Trends and Predictive Risk Factors in a Romanian Tertiary Care Centre.Antibiotics (Basel, Switzerland) · 2026Article
- Epidemiology of microbiological findings in the lower respiratory tract in mechanically ventilated patients with and without inhalation injury.Frontiers in cellular and infection microbiology · 2026Observational
- The relationship between the skin microbiome and probiotics in the healing of burn injuries.Folia microbiologica · 2025Review
- Review
- A research agenda for burn infection prevention: identifying knowledge gaps and prioritizing future directions.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Review
- Advancing injectable hydrogels for wound treatment: targeted control of oxidative stress toward personalized regeneration.Burns & trauma · 2025Review
- Examination of duodenal and colonic microbiome changes in mouse models of acute and chronic pancreatitis.Scientific reports · 2024Article
- Challenges Facing Two Outbreaks of Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2024Article
- Pathophysiology of Severe Burn Injuries: New Therapeutic Opportunities From a Systems Perspective.Journal of burn care & research : official publication of the American Burn Association · 2024Review
- Evolution, control and success of combination therapy with Ampicilin-sulbactam/Ceftazidime-Avibactam during a Carbapenem-Resistant Acinetobacter baumannii outbreak in burn Intensive Care Unit.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Article
- In silico analysis of intestinal microbial instability and symptomatic markers in mice during the acute phase of severe burns.BMC microbiology · 2024Article
- "Gut" to grips with the science of the microbiome - a symposium report.Gut microbiome (Cambridge, England) · 2024Article
- Effects of Factors Influencing Scar Formation on the Scar Microbiome in Patients with Burns.International journal of molecular sciences · 2023Article
- Detection of the Level of Interleukin-8 in the Serum of Burn Patients by ELISA Technique.Archives of Razi Institute · 2023Article
- Colonizing microbiota is associated with clinical outcomes in diabetic wound healing.Advanced drug delivery reviews · 2023Review
- Evolution and Transmission of Cefiderocol-Resistant Acinetobacter baumannii During an Outbreak in the Burn Intensive Care Unit.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- A photoactivatable and phenylboronic acid-functionalized nanoassembly for combating multidrug-resistant gram-negative bacteria and their biofilms.Burns & trauma · 2023Article
- The impact of gut microbiota changes on the intestinal mucus barrier in burned mice: a study using 16S rRNA and metagenomic sequencing.Burns & trauma · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Burn damage can lead to a state of immune dysregulation that facilitates the development of infections in patients. The most deleterious impact of this dysfunction is the loss of the skin's natural protective barrier. Furthermore, the risk of infection is exacerbated by protracted hospitalization, urinary catheters, endotracheal intubation, inhalation injury, arterial lines and central venous access, among other mainstays of burn care. Currently, infections comprise the leading cause of mortality after major burn injuries, which highlights the improvements observed over the last 50 years in the care provided to burn victims. The need to implement the empirical selection of antibiotic therapy to treat multidrug-resistant bacteria may concomitantly lead to an overall pervasiveness of difficult-to-treat pathogens in burn centres, as well as the propagation of antimicrobial resistance and the ultimate dysregulation of a healthy microbiome. While preliminary studies are examining the variability and evolution of human and mice microbiota, both during the early and late phase burn injury, one must consider that abnormal microbiome conditions could influence the systemic inflammatory response. A better understanding of the changes in the post-burn microbiome might be useful to interpret the provenance and subsequent development of infections, as well as to come up with inferences on the prognosis of burn patients. This review aims to summarise the current findings describing the microbiological changes in different organs and systems of burn patients and how these alterations affect the risks of infections, complications, and, ultimately, healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.