Evidence map›Paper›PMID 32821545›Full record

ArticlePeerJ2020

Functional characterization of the chlorzoxazone 6-hydroxylation activity of human cytochrome P450 2E1 allelic variants in Han Chinese.

Ting Wang, Huihui Du, Jingsong Ma, Lu Shen, Muyun Wei, Xianglong Zhao, Luan Chen, Mo Li, Guorong Li, Qinghe Xing and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Ting WangBio-X Institutes, Shanghai Jiaotong University, Shanghai, China.
Huihui DuBio-X Institutes, Shanghai Jiaotong University, Shanghai, China.
Jingsong MaBio-X Institutes, Shanghai Jiaotong University, Shanghai, China.
Lu ShenBio-X Institutes, Shanghai Jiaotong University, Shanghai, China.
Muyun WeiBio-X Institutes, Shanghai Jiaotong University, Shanghai, China.
Xianglong ZhaoBio-X Institutes, Shanghai Jiaotong University, Shanghai, China.
Luan ChenBio-X Institutes, Shanghai Jiaotong University, Shanghai, China.
Mo LiBio-X Institutes, Shanghai Jiaotong University, Shanghai, China.
Guorong LiSchool of Life Sciences, Shandong Normal University, Shandong, China.
Qinghe XingInstitutes of Biomedical Sciences, Fudan University, Shanghai, China.
Lin HeBio-X Institutes, Shanghai Jiaotong University, Shanghai, China.
Shengying QinBio-X Institutes, Shanghai Jiaotong University, Shanghai, China.
Shanghai Jiao Tong University · CNFudan University · CNJinan University · CNJining Medical University · CNShandong Normal University · CN

Funding

Sex differences in stress-alcohol interactions modulating amygdala activityR00AA021802 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI LOGRIP, MARIAN LEE · 2015 to 2017
$747k
Sex differences in stress-alcohol interactions modulating amygdala activityK99AA021802 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI LOGRIP, MARIAN LEE · 2013 to 2014
$279k
NIAAA NIH HHS K99 AA021802NIAAA NIH HHS R00 AA021802
6 · The paper itself

Abstract

backgroundsCytochrome P450 (P450) 2E1 is one of the primary enzymes responsible for the metabolism of xenobiotics, such as drugs and environmental carcinogens. The genetic polymorphisms of the

methodsTo investigate whether genetic variants identified in the

resultsThe prematurely terminated p.Arg337X variant enzyme was undetectable by western blotting and inactive toward chlorzoxazone 6-hydroxylation. The c.1263C>T and c.[517G>A;1263C>T] variant enzymes exhibited properties similar to those of the wild-type CYP2E1. The

conclusionsThese findings indicate that the genetic polymorphisms of

Indexed as

ChlorzoxazoneCytochrome P450 2E1 (CYP2E1)Enzyme activityGenetic polymorphismsMetabolism

Identifiers

PMID32821545
PMCPMC7397980
OpenAlexW3046799568

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.