Evidence map›Paper›PMID 32821537›Full record

ArticlePeerJ2020

Altered gut microbiota associated with symptom severity in schizophrenia.

Shijia Li, Min Zhuo, Xia Huang, Yuanyuan Huang, Jing Zhou, Dongsheng Xiong, Jiahui Li, Ya Liu, Zhilin Pan, Hehua Li and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 6 pooled it
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 6 syntheses or guidelines pooled it, 139 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Prebiotic Treatment in People With Schizophrenia.Journal of clinical psychopharmacology
    Trial
  9. Review
  10. Review
  11. Review
  12. Article
  13. Gut microbiota: contributing to high CVD prevalence in people living with schizophrenia?European archives of psychiatry and clinical neuroscience · 2026
    Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Potential value of oral Mogibacterium in major depressive disorder.Frontiers in cellular and infection microbiology · 2026
    Article
  19. Article
  20. Review

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Shijia LiSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou, Guangdong, China.
Min ZhuoSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou, Guangdong, China.
Xia HuangSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou, Guangdong, China.
Yuanyuan HuangThe Affifiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou, Guangdong, China.
Jing ZhouDepartment of Biomedical Engineering, School of Material Science and Engineering, South China University of Technology, Guangzhou, Guangdong, China.
Dongsheng XiongDepartment of Biomedical Engineering, School of Material Science and Engineering, South China University of Technology, Guangzhou, Guangdong, China.
Jiahui LiDepartment of Biomedical Engineering, School of Material Science and Engineering, South China University of Technology, Guangzhou, Guangdong, China.
Ya LiuDepartment of Biomedical Engineering, School of Material Science and Engineering, South China University of Technology, Guangzhou, Guangdong, China.
Zhilin PanDepartment of Biomedical Engineering, School of Material Science and Engineering, South China University of Technology, Guangzhou, Guangdong, China.
Hehua LiThe Affifiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou, Guangdong, China.
Jun ChenGuangdong Engineering Technology Research Center for Diagnosis and Rehabilitation of Dementia, Guangzhou, Guangdong, China.
Xiaobo LiGuangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, Guangdong, China.
Zhiming XiangGuangdong Engineering Technology Research Center for Diagnosis and Rehabilitation of Dementia, Guangzhou, Guangdong, China.
Fengchun WuThe Affifiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou, Guangdong, China.
Kai WuDepartment of Biomedical Engineering, School of Material Science and Engineering, South China University of Technology, Guangzhou, Guangdong, China.ORCID 0000-0003-4467-1597
South China University of Technology · CNGuangzhou Medical University · CNNew Jersey Institute of Technology · USPanyu District Central Hospital · CNTohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe gut microbiome and microbiome-gut-brain (MGB) axis have been receiving increasing attention for their role in the regulation of mental behavior and possible biological basis of psychiatric disorders. With the advance of next-generation sequencing technology, characterization of the gut microbiota in schizophrenia (SZ) patients can provide rich clues for the diagnosis and prevention of SZ.

methodsIn this study, we compared the differences in the fecal microbiota between 82 SZ patients and 80 demographically matched normal controls (NCs) by 16S rRNA sequencing and analyzed the correlations between altered gut microbiota and symptom severity.

resultsThe alpha diversity showed no significant differences between the NC and SZ groups, but the beta diversity revealed significant community-level separation in microbiome composition between the two groups (pseudo-

conclusionsOur findings provided evidence of altered gut microbial composition in SZ group. In addition, we found that

Indexed as

16S rRNA sequencingGut microbiotaMicrobiome-Gut-Brain axisPANSSSchizophrenia

Identifiers

PMID32821537
PMCPMC7395597
OpenAlexW3045895528

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.