Evidence map›Paper›PMID 32821510›Full record

ArticleTranslational vision science & technology2020

Feature Counting Under Dichoptic Viewing in Anisometropic and Strabismic Amblyopia.

Audrey Marie Beatrice Wong-Kee-You, Hong Wei, Chuan Hou

Open access · goldAbstract read
In one paragraph

Article in Translational vision science & technology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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  8. Rethinking amblyopia 2020.Vision research · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Audrey Marie Beatrice Wong-Kee-YouSmith-Kettlewell Eye Research Institute, San Francisco, CA, USA.
Hong WeiDepartment of Ophthalmology and Vision Research Laboratory, West China Hospital, Sichuan University, Chengdu, China.
Chuan HouSmith-Kettlewell Eye Research Institute, San Francisco, CA, USA.
Smith-Kettlewell Eye Research Institute · USWest China Hospital of Sichuan University · CN

Funding

Interocular Suppression and Selective Attention in AmblyopiaR01EY025018 · NEI · SMITH-KETTLEWELL EYE RESEARCH INSTITUTE · PI HOU, CHUAN · 2016 to 2020
$2.1M
NEI NIH HHS R01 EY025018
6 · The paper itself

Abstract

Purpose: While using their amblyopic eye, individuals with strabismic amblyopia count inaccurately and underestimate the number of features. These deficits are attributed to limitations in high-level cortical functions and attention. In the current study, we examined whether feature counting is affected in strabismic and anisometropic amblyopia during dichoptic viewing, a setup that can better capture binocular function disruptions. Methods: Through a mirror stereoscope, Gabor patches were presented for 200 msec (Experiment 1) or 350 msec (Experiment 2) in both the left eye and the right eye of observers, who were required to combine the percepts and report the total number of patches. Counting performance and errors were compared across amblyopic groups and normal-sighted observers. The contribution and relation of each eye to performance was also evaluated. Results: Anisometropic and strabismic amblyopia groups counted inaccurately and underestimated the number of features compared to the normal-sighted group. In both amblyopic groups, the amblyopic eye contributed less in comparison to the fellow eye. The strabismic group exhibited worse performance, and a more pronounced difference in eye contribution, in comparison to the anisometropic group. Conclusions: Overall, our results support the view of higher-level cortical and binocular function deficits in amblyopia. Translational Relevance: The current study bridges the gap between research on high-cortical function deficits and clinical binocular function disruptions in amblyopia, which can help us better understand the neural mechanism of amblyopia and inform clinical therapeutic tasks and strategies.

Indexed as

AmblyopiaStrabismusAttentionEyeHumansVisual Acuityamblyopiaanisometropiabinocular disfunctionfeature countingstrabismus

Identifiers

PMID32821510
PMCPMC7408935
OpenAlexW3025641046

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.