Evidence map›Paper›PMID 32821502›Full record

ArticleTranslational vision science & technology2020

Chromatic Pupil Campimetry Reveals Functional Defects in Exudative Age-Related Macular Degeneration with Differences Related to Disease Activity.

Carina Kelbsch, Jakob Lange, Helmut Wilhelm, Barbara Wilhelm, Tobias Peters, Melanie Kempf, Laura Kuehlewein, Krunoslav Stingl

Open access · goldAbstract read
In one paragraph

Article in Translational vision science & technology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  6. Diagnostic performance of pupil perimetry in detecting hemianopia under standard and virtual reality viewing conditions.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
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  7. Article
  8. Review
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  11. Central retina plays a decisive role in the suppression of pupillary escape.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023
    Article
  12. Article
  13. Article
  14. How lesions at different locations along the visual pathway influence pupillary reactions to chromatic stimuli.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022
    Article
  15. Article
  16. Evaluation of Local Rod and Cone Function in Stargardt Disease.Investigative ophthalmology & visual science · 2022
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  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Carina KelbschUniversity Eye Hospital, Centre for Ophthalmology, University of Tübingen, Tübingen, Germany.
Jakob LangePupil Research Group, Centre for Ophthalmology, University of Tübingen, Tübingen, Germany.
Helmut WilhelmUniversity Eye Hospital, Centre for Ophthalmology, University of Tübingen, Tübingen, Germany.
Barbara WilhelmPupil Research Group, Centre for Ophthalmology, University of Tübingen, Tübingen, Germany.
Tobias PetersPupil Research Group, Centre for Ophthalmology, University of Tübingen, Tübingen, Germany.
Melanie KempfUniversity Eye Hospital, Centre for Ophthalmology, University of Tübingen, Tübingen, Germany.
Laura KuehleweinUniversity Eye Hospital, Centre for Ophthalmology, University of Tübingen, Tübingen, Germany.
Krunoslav StinglUniversity Eye Hospital, Centre for Ophthalmology, University of Tübingen, Tübingen, Germany.
University of Tübingen · DESTZ eyetrial · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: The purpose of this study was to use chromatic pupil campimetry (CPC) for an objective evaluation of local retinal function in exudative age-related macular degeneration (AMD) and to assess disease activity. Methods: Gaze-controlled CPC was performed in 19 subjects with optical coherence tomography-confirmed exudative AMD (75 ± 4 years; 11 women) and the results compared with those of an age-matched control group (n = 11; 72 ± 6 years; 8 women). Local retinal function was evaluated by measuring pupil responses to 3° red stimuli (60 cd/m Results: Pupil constriction amplitudes were significantly reduced in the macular region, and especially in the fovea in AMD (16% ± 4.7%; mean ± standard deviation), compared with the control group (24% ± 6%; Conclusions: CPC detected functional changes in exudative AMD with high sensitivity. Time dynamics of active exudative AMD differed from disease inactivity. Translational Relevance: With the combination of short recording time, objectiveness of the measurement and gaze-correction for fixation problems, this method presents a suitable complement to the currently used clinical functional tests of the macula.

Indexed as

Macular DegenerationVisual Field TestsAgedFemaleHumansPupilVisual AcuityVisual Fieldsage-related macular degenerationexudative AMDobjective measurementpupil campimetrypupillometryretinal function

Identifiers

PMID32821502
PMCPMC7409006
OpenAlexW3022891637

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.