Evidence map›Paper›PMID 32821496›Full record

ArticleTranslational vision science & technology2020

Comparison of the Morphology of the Foveal Pit Between African and Caucasian Populations.

Moussa A Zouache, Giuliana Silvestri, Winfried M Amoaku, Vittorio Silvestri, William C Hubbard, Christian Pappas, Stephen Akafo, Seth Lartey, Rebecca R Mastey, Joseph Carroll and 1 more

Abstract read
In one paragraph

Article in Translational vision science & technology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Clinical anatomy of the macula.Medical hypothesis, discovery & innovation ophthalmology journal · 2025
    Review
  8. Review
  9. In Vivo Assessment of Retinal Phenotypes in Axenfeld-Rieger Syndrome.Investigative ophthalmology & visual science · 2024
    Article
  10. Article
  11. The effect of ethnicity on anatomic success following macular hole surgery: a multicentre cohort study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023
    Article
  12. Insights into the developing fovea revealed by imaging.Progress in retinal and eye research · 2022
    Review
  13. Foveal Curvature and Its Associations in UK Biobank Participants.Investigative ophthalmology & visual science · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Moussa A ZouacheSteele Center for Translational Medicine, John A. Moran Eye Center, Department of Ophthalmology & Visual Sciences, University of Utah, Salt Lake City, UT, USA.
Giuliana SilvestriOphthalmology Department, Belfast Health and Social Care Trust, Belfast, UK.
Winfried M AmoakuAcademic Ophthalmology and Visual Sciences, DCN, University of Nottingham and University Hospitals, Nottingham, UK.
Vittorio SilvestriNICRN, Belfast Health and Social Care Trust, Belfast, UK.
William C HubbardSteele Center for Translational Medicine, John A. Moran Eye Center, Department of Ophthalmology & Visual Sciences, University of Utah, Salt Lake City, UT, USA.
Christian PappasSteele Center for Translational Medicine, John A. Moran Eye Center, Department of Ophthalmology & Visual Sciences, University of Utah, Salt Lake City, UT, USA.
Stephen AkafoUnit of Ophthalmology, Department of Surgery, University of Ghana Medical School, Korle Bu, Accra, Ghana.
Seth LarteyEye Unit, Eye Ear Nose and Throat Department, Komfo Anokye Teaching Hospital and Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Rebecca R MasteyDepartment of Ophthalmology & Visual Sciences, Medical College of Wisconsin Eye Institute, Milwaukee, WI, USA.
Joseph CarrollDepartment of Ophthalmology & Visual Sciences, Medical College of Wisconsin Eye Institute, Milwaukee, WI, USA.
Gregory S HagemanSteele Center for Translational Medicine, John A. Moran Eye Center, Department of Ophthalmology & Visual Sciences, University of Utah, Salt Lake City, UT, USA.

Funding

Development of Complement Modulating Therapeutics for AMDR24EY017404 · NEI · UNIVERSITY OF UTAH · PI HAGEMAN, GREGORY S · 2006 to 2010
$14.8M
Retinal Versus Cortical Contributions to Vision Loss in AlbinismR01EY024969 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI CARROLL, JOSEPH, DEYOE, EDGAR A · 2015 to 2018
$2.0M
NEI NIH HHS R01 EY024969NEI NIH HHS R24 EY017404
6 · The paper itself

Abstract

Purpose: The purpose of this study was to characterize foveal pit morphology in an African (Ghanaian) population, to compare it to that of a Caucasian group and to determine if it varied with age in the two populations. Methods: The depth, diameter, slope, and volume of the foveal pit were interpolated from optical coherence tomography volume scans recorded in 84 Ghanaian and 37 Caucasian individuals. Their association with age, sex, and ethnicity was investigated using multilevel regression models. Results: The foveal pit differed significantly in width, slope, and volume between Ghanaian men and women ( Conclusions: The morphology of the foveal pit differs between African and Caucasian individuals. These anatomic differences should be considered when examining differences in prevalence and clinical features of vitreoretinal disorders involving the fovea between the two populations. Translational Relevance: Differences in retinal anatomy may partly explain variations in the prevalence and clinical features of retinal diseases between Africans and Caucasians. Such differences should be adequately considered in diagnoses and monitoring of ocular diseases in patients with African ancestry.

Indexed as

Fovea CentralisWhite PeopleFemaleGhanaHumansMaleRetinaTomography, Optical Coherenceanatomyfoveamaculaoptical coherence tomographyretina

Identifiers

PMID32821496
PMCPMC7401974

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.