ArticleJournal of animal science and biotechnology2020
Profiling of miRNAs in porcine Sertoli cells.
Article in Journal of animal science and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- miR-132-y TargetsBiomolecules · 2026Article
- CircRNA profiling reveals the regulatory role of circPAN3 in Hezuo boars Sertoli cell growth.BMC genomics · 2024Article
- Stage-specific expression of Toll-like receptors in the seminiferous epithelium of mouse testis.Histochemistry and cell biology · 2024Article
- MicroRNAs in spermatogenesis dysfunction and male infertility: clinical phenotypes, mechanisms and potential diagnostic biomarkers.Frontiers in endocrinology · 2024Review
- Circulating microRNAs as promising testicular translatable safety biomarkers: current state and future perspectives.Archives of toxicology · 2023Review
- Integrative transcriptomic profiling of mRNA, miRNA, circRNA, and lncRNA in alveolar macrophages isolated from PRRSV-infected porcine.Frontiers in immunology · 2023Article
- miRNA-Profiling in Ejaculated and Epididymal Pig Spermatozoa and Their Relation to Fertility after Artificial Insemination.Biology · 2022Article
- Transcriptome sequencing reveals differences between leydig cells and sertoli cells of yak.Frontiers in veterinary science · 2022Article
- circBTBD7 Promotes Immature Porcine Sertoli Cell Growth through Modulating miR-24-3p/International journal of molecular sciences · 2021Article
- Identification of microRNA-Associated-ceRNA Networks Regulating Crop Milk Production in Pigeon (Genes · 2020Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSertoli cells (SCs) create a specialized environment to support and dictate spermatogenesis. MicroRNAs (miRNAs), a kind of ~ 22 nt small noncoding RNAs, have been reported to be highly abundant in mouse SCs and play critical roles in spermatogenesis. However, the miRNAs of porcine SCs remain largely unknown.
methodsWe isolated porcine SCs and conducted small RNA sequencing. By comparing miRNAs in germ cells, we systematically analyzed the miRNA expression pattern of porcine SCs. We screened the highly enriched SC miRNAs and predicted their functions by Gene Ontology analysis. The dual luciferase assay was used to elucidate the regulation of tumor necrosis factor receptor (TNFR)-associated factor 3 (
resultsThe analysis showed that 18 miRNAs were highly expressed in SCs and 15 miRNAs were highly expressed in germ cells. These miRNAs were predicted to mediate SC and germ cell functions. In addition,
conclusionOur findings provide novel insights into the miRNA expression pattern and their regulatory roles of porcine SCs.
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