Evidence map›Paper›PMID 32821342›Full record

ArticleOncotarget2020

Thymoquinone induces apoptosis and DNA damage in 5-Fluorouracil-resistant colorectal cancer stem/progenitor cells.

Farah Ballout, Alissar Monzer, Maamoun Fatfat, Hala El Ouweini, Miran A Jaffa, Rana Abdel-Samad, Nadine Darwiche, Wassim Abou-Kheir, Hala Gali-Muhtasib

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Farah BalloutDepartment of Biology, American University of Beirut, Lebanon.
Alissar MonzerDepartment of Biology, American University of Beirut, Lebanon.
Maamoun FatfatDepartment of Biology, American University of Beirut, Lebanon.
Hala El OuweiniDepartment of Biology, American University of Beirut, Lebanon.
Miran A JaffaDepartment of Epidemiology and Population Health, American University of Beirut, Lebanon.
Rana Abdel-SamadDepartment of Biochemistry and Molecular Genetics, American University of Beirut, Lebanon.
Nadine DarwicheDepartment of Biochemistry and Molecular Genetics, American University of Beirut, Lebanon.
Wassim Abou-KheirCenter for Drug Discovery and Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Lebanon.
Hala Gali-MuhtasibDepartment of Biology, American University of Beirut, Lebanon.
American University of Beirut · LB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The high recurrence rates of colorectal cancer have been associated with a small population of cancer stem cells (CSCs) that are resistant to the standard chemotherapeutic drug, 5-fluorouracil (5FU). Thymoquinone (TQ) has shown promising antitumor properties on numerous cancer systems both

Indexed as

5-Fluorouracil resistanceapoptosiscolonospherescolorectal cancer stem cellsthymoquinone

Identifiers

PMID32821342
PMCPMC7415406
OpenAlexW3047397125

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.