Evidence map›Paper›PMID 32821282›Full record

ArticleEvolutionary applications2020

The special issue on cancer and evolution: Lessons learned.

James DeGregori

Abstract read
In one paragraph

Article in Evolutionary applications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

James DeGregoriDepartment of Biochemistry and Molecular Genetics Department of Immunology and Microbiology University of Colorado Anschutz Medical Campus Aurora CO USA.ORCID https://orcid.org/0000-0002-1287-1976

Funding

Preventing Cognitive Decline and Dementia Among Older Chinese Immigrants: The Role of Activity, Engagement, Immigration Experience, and Neighborhood EnvironmentsR01AG067548 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TANG, FENGYAN · 2020 to 2023
$2.2M
Determining how aging-associated changes in the microenvironment contribute to leukemogenesisR01AG067584 · NIA · UNIVERSITY OF COLORADO DENVER · PI DEGREGORI, JAMES V · 2019 to 2022
$1.7M
Aged tissue environments as drivers of oncogenic adaptation in hematopoiesisR01AG066544 · NIA · UNIVERSITY OF COLORADO DENVER · PI DEGREGORI, JAMES V · 2020 to 2024
$1.1M
Understanding and circumventing aging-dependent changes in the bone marrow microenvironment that promote leukemogenesisU01AG066099 · NIA · UNIVERSITY OF COLORADO DENVER · PI DEGREGORI, JAMES V · 2019 to 2020
$226k
NIA NIH HHS R01 AG066544NIA NIH HHS R01 AG067548NIA NIH HHS R01 AG067584NIA NIH HHS U01 AG066099
6 · The paper itself

Abstract

This special issue of evolutionary applications focused on the evolution of cancer has provided a wealth of different viewpoints and results from leaders in the field. Together, these papers emphasize the importance of a broad perspective in order to understand why we and other animals get cancer, how it evolves within an individual, and what we can do about it. We can no longer take reductionist approaches that consider only the cancer cells and their genes. Instead, we need to understand how millions of years of evolution have guided strategies that shape cancer risk, why cancer risk varies across different animals, how cancer risk can vary in a population and be influenced by ecology (and influence this ecology), and of course how cancers evolve within us and the evolutionarily informed strategies to counter their impact. My goal here will be to "bring it all home," providing a refresher of lessons learned with added kibitzing.

Indexed as

cancer evolutioncancer risk and oncogenesissomatic evolutiontransmissible cancers

Identifiers

PMID32821282
PMCPMC7428814

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.