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ArticleInternational medical case reports journal2020

Fever with Rash is One of the First Presentations of COVID-19 in Children: A Case Report.

Mohammad Reza Navaeifar, Mehrdad Poudineh Ghazaghi, Leila Shahbaznejad, Hamed Rouhanizadeh, Mahnush Abutalebi, Mobina Ranjbar Varandi, Mohammad Sadegh Rezai

Abstract readCase Reports
In one paragraph

Article in International medical case reports journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. COVID-19 cutaneous manifestations in children and adolescents: a systematic review.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2022
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  7. Insights into urticaria in pediatric and adult populations and its management with fexofenadine hydrochloride.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mohammad Reza NavaeifarPediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran.ORCID 0000-0001-9752-5484
Mehrdad Poudineh GhazaghiFaculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.ORCID 0000-0003-4792-8968
Leila ShahbaznejadPediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Hamed RouhanizadehPediatric Department, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Mahnush AbutalebiFaculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Mobina Ranjbar VarandiFaculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.ORCID 0000-0001-9338-053X
Mohammad Sadegh RezaiPediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran.ORCID 0000-0003-4585-9954

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionClinical presentations of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vary among patients, which make a confusing challenge for clinicians to diagnose the disease. While the disease is not rare, but the symptoms may be atypical in children. CASE PRESENTATION: A 12-month-old boy with fever and rash without respiratory complaints at the onset of the disease presented to the hospital. His illness was then accompanied by severe anemia, hypoalbuminemia, hypoxemia, and pleural effusion. The nasopharyngeal swab polymerase chain reaction test was positive for the novel coronavirus. Despite primary normal lung imaging, the second imaging was typical for the disease on the third day of admission. DISCUSSION: Dermatologic manifestations of the novel coronavirus infection are not rare during the illness but rarely occur at the onset of the disease. Information about the cutaneous manifestations of SARS-CoV-2 and its time interval from the onset of the disease in children are not clear yet. Severe anemia, hypoalbuminemia, and pleural effusion are not reported as classic findings of the novel SARS-CoV-2. They may be considered as a consequence of the hyperinflammatory response or direct effect of the virus.

conclusionAs a different manifestation of SARS-CoV-2, infected children may initially present fever and rash. More studies are needed to discover the cause of these complications. The correct answer may lead to better insight and more effective treatment.

Indexed as

childrenCOVID-19feverrashSARS-CoV-2

Identifiers

PMID32821174
PMCPMC7425085

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.