ArticleClinical interventions in aging2020
Hormonal Function Responses to Moderate Aerobic Exercise in Older Adults with Depression.
Article in Clinical interventions in aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Interplay between frailty and cardiometabolic disorders: from pathophysiology to clinical implications.Cardiovascular diabetology · 2025Pooled it
- Mechanisms Linking Physical Activity with Psychiatric Symptoms Across the Lifespan: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2023Pooled it
- Article
- The Relationship Between Physical Activity and Problematic Internet Use in Turkish College Students: The Chain-Mediated Role of Self-Control and Distress.The Psychiatric quarterly · 2025Article
- Neuroimaging biomarkers of neuroprotection: Impact of voluntary versus enforced exercise in Alzheimer's disease models.Magnetic resonance imaging · 2025Article
- Impact of aerobic exercise on chronic inflammation in older adults: a systematic review and meta-analysis.BMC sports science, medicine & rehabilitation · 2025Article
- Association between social media use, physical activity level, and depression and anxiety among college students: a cross-cultural comparative study.Scientific reports · 2025Article
- Article
- From movement to motivation: a proposed framework to understand the antidepressant effect of exercise.Translational psychiatry · 2024Review
- Effects of High-Intensity Interval Training on Melatonin Function and Cellular Lymphocyte Apoptosis in Sedentary Middle-Aged Men.Medicina (Kaunas, Lithuania) · 2023Article
- Beyond the treatment: The role of race, sex, and education in health trajectories between cancer survivors and noncancer older adults.Journal of geriatric oncology · 2023Article
- Conserved multi-tissue transcriptomic adaptations to exercise training in humans and mice.Cell reports · 2023Article
- Socioeconomic, Behavioural, and Social Health Correlates of Optimism and Pessimism in Older Men and Women: A Cross-Sectional Study.International journal of environmental research and public health · 2023Article
- Moderate-intensity aerobic exercise training as an adjunct to trauma-focused psychotherapy in traumatized refugees and asylum seekers: study protocol of a randomized controlled trial.European journal of psychotraumatology · 2023Article
- Mechanisms through which exercise reduces symptom severity and/or functional impairment in posttraumatic stress disorder (PTSD): Protocol for a living systematic review of human and non-human studies.Wellcome open research · 2023Article
- Effects of Lifestyle Factors on Cognition in Minority Population of Older Adults: A Review.Frontiers in nutrition · 2022Review
- Circulating microRNAs and Molecular Oxidative Stress in Older Adults with Neuroprogression Disorders.Disease markers · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPoor daily life physical activities among older people were related to depressive mood especially memory loss. In addition to that, the change in physical ability is significantly associated with the score of depression among older age.
objectiveThe present study aimed to evaluate the effects of a supervised aerobic training program with moderate intensity for 12 weeks on mood profiles and hormonal levels of the hypothalamus-pituitary-adrenal axis (HPA axis) of older adults.
methodsA total of 80 individuals of both gender (90 males, 110 females) of ages ranged between 65 and 95 years were recruited for this study. Based upon the profile of mood states (POMS) analysis, the participants were classified into two groups: control group (n=30) and depressive group (n=50). Leisure-time physical activity (LTPA), adrenal hormones such as ACTH, corticosterone (CORT), cortisol, DHEA/S, and cortisol:DHEA/S ratio were measured at baseline and post-intervention of moderate aerobic exercise for 12 weeks.
resultsOlder adults with higher depressive scores showed a remarkable change in the level of adrenal hormones compared to control. There was a significant increase in the level of ACTH, CORT, cortisol, and cortisol:DHEA/S ratio, and decrease in DHEA/S. Compared to females, males showed an improvement in depressive mood score along with an increase in LPTA, DHEA/S and decrease in ACTH, CORT, cortisol, cortisol:DHEA/S ratio following 12 weeks of supervised aerobic training, respectively.
conclusionThe findings of this study showed that 12 weeks of supervised exercise interventions are promising non-drug therapeutic strategies in improving depression among older adults. The potential performance in a psychological state occurs physiologically via optimizing the levels of the hormones of the HPA axis.
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