ArticleJournal of clinical research in pediatric endocrinology2021
Frequency of Celiac Disease and Spontaneous Normalization Rate of Celiac Serology in Children and Adolescent Patients with Type 1 Diabetes
Article in Journal of clinical research in pediatric endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05442398 (Detection of Celiac Disease Among Suspected Patients With Type 1 Diabetes Mellitus), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Detection of Celiac Disease Among Suspected Patients With Type 1 Diabetes Mellitus
Who cites it
16 citing papers in PubMed, 49 citations in OpenAlex.
- Predictors of Progression to Villous Atrophy in Children with Type 1 Diabetes and Potential Celiac Disease.Digestive diseases and sciences · 2026Article
- Celiac disease and celiac serology in children with Type 1 Diabetes: diagnostic timing, serologic patterns, and implications for long-term management.Pediatric diabetes · 2026Article
- The Implications of Type 1 Diabetes Mellitus Associated with Coeliac Disease.Journal of clinical medicine · 2025Review
- Prevalence of autoimmune diseases in patients with type 1 diabetes: a scoping review.Einstein (Sao Paulo, Brazil) · 2025Article
- Celiac disease autoimmunity among Nigerian children and adolescents with type 1 diabetes mellitus.BMC gastroenterology · 2024Article
- A Clinician's Guide to Gluten Challenge.Journal of pediatric gastroenterology and nutrition · 2023Review
- The Screening of Celiac Serology in Pediatric Patients Diagnosed with Type 1 Diabetes Mellitus.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2023Article
- Celiac Disease Genetics, Pathogenesis, and Standard Therapy for Japanese Patients.International journal of molecular sciences · 2023Review
- Revisiting the Annual Incidence of Type 1 Diabetes Mellitus in Children from the Southeastern Anatolian Region of Turkey: A Regional ReportJournal of clinical research in pediatric endocrinology · 2022Article
- HLA DQ2/DQ8 haplotypes and anti-transglutaminase antibodies as celiac disease markers in a pediatric population with type 1 diabetes mellitus.Archives of endocrinology and metabolism · 2022Observational
- Recommendations for Clinical Decision-making in Children with Type 1 Diabetes and Celiac Disease: Type 1 Diabetes and Celiac Disease Joint Working Group ReportJournal of clinical research in pediatric endocrinology · 2022Article
- Review
- Could I-FABP Be an Early Marker of Celiac Disease in Children with Type 1 Diabetes? Retrospective Study from the Tertiary Reference Centre.Nutrients · 2022Article
- Circulating circular RNA profiles associated with celiac disease seropositivity in children with type 1 diabetes.Frontiers in pediatrics · 2022Article
- The when, why and whom to biopsy of type 1 diabetes mellitus children with positive anti-tissue transglutaminase serology.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
- Frequency and predictive factors for spontaneous normalization of anti-tissue transglutaminase-IgA serology among Saudi children with type 1 diabetes mellitus: A cohort study.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The prevalence of celiac disease (CD) varies between 1% and 10% in patients with type 1 diabetes mellitus (T1DM). This study aimed to determine the frequency of spontaneous recovery of celiac serology and the biopsy-proven CD (BPCD) frequency in patients with T1DM. Methods: The data of 668 patients with available celiac serology tests from a total of 779 patients who were followed for the last 10 years with the diagnosis of T1DM were retrospectively evaluated. Results: Positive serology was detected in 103 out of 668 (15.4%) patients. There was spontaneous normalization in 24 (23.3%), fluctuation in 11 (10.7%) and permanently positive serology in 68 (66%). In 46 out of 53 (86.8%) patients with positive serology and biopsy, CD diagnosis was confirmed by biopsy (BPCD). The frequency of BPCD was 6.9%, and the serology in 76.1% was positive at the time of diagnosis of T1DM. The weight, height and body mass index-standard deviation score at diagnosis were lower in patients with BPCD compared to the group without CD. An anti-tissue transglutaminase-IgA (anti-TTG-IgA) level of 11.8 times the upper limit of normal was the most sensitive (93%) and specific (90%) cut-off for BPCD (area under the curve: 0.95; 95% confidence interval: 0.912-1; p<0.001). Conclusion: In our cohort, the frequency of positive serology for CD was 15.4%, while the rate of BPCD was 6.9%. The majority (97.8%) of cases were diagnosed within the first five years of T1DM. In 23.3% of cases, positive anti-TTG-IgA spontaneously resolved without a gluten-free diet (GFD). Therefore, serological follow-up instead of immediate duodenal biopsy or GFD therapy, particularly for patients with asymptomatic and mild anti-TTG IgA level, is warranted.
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