ArticleHuman brain mapping2020
Decreased cortical thickness mediates the relationship between premature birth and cognitive performance in adulthood.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Decreased amygdala volume in adults after premature birth.Scientific reports · 2021Trial
- Longitudinal assessment of cortical thickness in healthy older individuals: a comparison between CAT12 and freesurfer.Neuroradiology · 2026Article
- Heterogeneous, temporally consistent, and plastic brain development after preterm birth.Nature communications · 2025Article
- The impact of different types of brain injuries on cerebral perfusion in preterm infants: an arterial spin labeling : MRI study.Scientific reports · 2025Article
- Ascending Vaginal Infection in Mice Induces Preterm Birth and Neonatal Morbidity.The American journal of pathology · 2025Article
- Motor predictors of cortical brain development and full-IQ in children born extremely preterm with and without discrete white matter abnormalities.Brain structure & function · 2024Article
- Interactive roles of preterm-birth and socioeconomic status in cortical thickness of language-related brain structures: Findings from the Adolescent Brain Cognitive Development (ABCD) study.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Language performance and brain volumes, asymmetry, and cortical thickness in children born extremely preterm.Pediatric research · 2024Article
- Association between cortical thickness and cognitive ability in very preterm school-age children.Scientific reports · 2024Article
- Altered gray-to-white matter tissue contrast in preterm-born adults.CNS neuroscience & therapeutics · 2023Article
- Indirect evidence for altered dopaminergic neurotransmission in very premature-born adults.Human brain mapping · 2023Article
- Cerebral blood flow patterns in preterm and term neonates assessed with pseudo-continuous arterial spin labeling perfusion MRI.Human brain mapping · 2023Article
- Article
- Lower cortical thickness and increased brain aging in adults with cocaine use disorder.Frontiers in psychiatry · 2023Article
- Aberrant allometric scaling of cortical folding in preterm-born adults.Brain communications · 2023Article
- Within amygdala: Basolateral parts are selectively impaired in premature-born adults.NeuroImage. Clinical · 2021Article
- Decreased cortical thickness mediates the relationship between premature birth and cognitive performance in adulthood.Human brain mapping · 2020Article
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15 authors.
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Abstract
Cortical thickness (CTh) reflects cortical properties such as dendritic complexity and synaptic density, which are not only vulnerable to developmental disturbances caused by premature birth but also highly relevant for cognitive performance. We tested the hypotheses whether CTh in young adults is altered after premature birth and whether these aberrations are relevant for general cognitive abilities. We investigated CTh based on brain structural magnetic resonance imaging and surface-based morphometry in a large and prospectively collected cohort of 101 very premature-born adults (<32 weeks of gestation and/or birth weight [BW] below 1,500 g) and 111 full-term controls at 26 years of age. Cognitive performance was assessed by full-scale intelligence quotient (IQ) using the Wechsler Adult Intelligence Scale. CTh was reduced in frontal, parietal, and temporal associative cortices predominantly in the left hemisphere in premature-born adults compared to controls. We found a significant positive association of CTh with both gestational age and BW, particularly in the left hemisphere, and a significant negative association between CTh and intensity of neonatal treatment within limited regions bilaterally. Full-scale IQ and CTh in the left hemisphere were positively correlated. Furthermore, CTh in the left hemisphere acted as a mediator on the association between premature birth and full-scale IQ. Results provide evidence that premature born adults have widespread reduced CTh that is relevant for their general cognitive performance. Data suggest lasting reductions in cortical microstructure subserving CTh after premature birth.
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