Evidence map›Paper›PMID 32820777›Full record

ArticleChemical communications (Cambridge, England)2020

Sequence-defined vinyl sulfonamide click nucleic acids (VS-CNAs) and their assembly into dynamically responsive materials.

Bryan P Sutherland, Paige J LeValley, Derek J Bischoff, April M Kloxin, Christopher J Kloxin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical communications (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bryan P SutherlandDepartment of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA. cjk@udel.edu.ORCID http://orcid.org/0000-0002-1583-4601
Paige J LeValleyDepartment of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA.ORCID http://orcid.org/0000-0002-5716-6031
Derek J BischoffDepartment of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA. cjk@udel.edu.ORCID http://orcid.org/0000-0003-2267-1959
April M KloxinDepartment of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA. cjk@udel.edu and Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA.ORCID http://orcid.org/0000-0002-4594-2953
Christopher J KloxinDepartment of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA. cjk@udel.edu and Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA.ORCID http://orcid.org/0000-0002-1679-0022

Funding

This renovation project will create over 1455 sq. ft. of state- of-the-art reseaP20GM104316 · NIGMS · UNIVERSITY OF DELAWARE · PI SCHMITZ, KARL ROBERT · 2014 to 2024
$26.8M
Pilot Research Subproject ProgramP30GM110758 · NIGMS · UNIVERSITY OF DELAWARE · PI BEEBE, THOMAS PAUL · 2014 to 2018
$5.8M
Unraveling fibrosis with dynamic microenvironments and molecular toolsDP2HL152424 · NHLBI · UNIVERSITY OF DELAWARE · PI KLOXIN, APRIL M · 2019 to 2019
$2.4M
NHLBI NIH HHS DP2 HL152424NIGMS NIH HHS P20 GM104316NIGMS NIH HHS P30 GM110758
6 · The paper itself

Abstract

Synthetic DNA analogues are of great interest for their application in information storage, therapeutics, and nanostructured materials, yet are often limited in scalability. Vinyl sulfonamide click nucleic acids (VS-CNAs) have been developed to overcome this limitation using the highly efficient thiol-Michael 'click' reaction. Utilizing all four nucleobases, sequence-defined click nucleic acids (CNAs) were synthesized using a simple and scalabale solution-phase approach. Employing a polyethylene glycol (PEG) support, synthesis of the CNA sequence, GATTACA, was achieved in high yields. CNA crosslinked hydrogels were assembled using multiarm PEG-CNAs resulting in materials that dynamically respond to temperature, strain, and competitive sequences.

Indexed as

DNAHydrogelsMaterials TestingPolyethylene GlycolsSulfonamidesTemperatureDNAHydrogelsPolyethylene GlycolsSulfonamidesvinyl sulfonamide

Identifiers

PMID32820777
PMCPMC7530108

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.