Evidence map›Paper›PMID 32820720›Full record

ArticleeLife2020

β-catenin and γ-catenin are dispensable for T lymphocytes and AML leukemic stem cells.

Xin Zhao, Peng Shao, Kexin Gai, Fengyin Li, Qiang Shan, Hai-Hui Xue

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. All-trans retinoic acid suppresses CD8Signal transduction and targeted therapy · 2026
    Article
  2. CD8Cell reports. Medicine · 2026
    Review
  3. Junction Plakoglobin - A Dual-Role Player in Cancer Biology.International journal of surgery (London, England) · 2025
    Review
  4. Review
  5. Epithelial-Mesenchymal Transition in Acute Leukemias.International journal of molecular sciences · 2024
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. TCF1 in T cell immunity: a broadened frontier.Nature reviews. Immunology · 2022
    Review
  14. TProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Xin Zhao *Center for Discovery and Innovation, Hackensack University Medical Center, Nutley, United States.
Peng Shao *Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, United States.
Kexin GaiCenter for Discovery and Innovation, Hackensack University Medical Center, Nutley, United States.
Fengyin LiHefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Qiang ShanCenter for Discovery and Innovation, Hackensack University Medical Center, Nutley, United States.
Hai-Hui XueCenter for Discovery and Innovation, Hackensack University Medical Center, Nutley, United States.ORCID 0000-0002-9163-7669
Hackensack University Medical Center · USUniversity of Iowa · USUniversity of Science and Technology of China · CN

Funding

RESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0M
Tcf/Lef-b-catenin in T cell identity and cancerR01AI112579 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2015 to 2026
$5.4M
Tcf/Lef and B-catenin pathway in follicular helper T cellsR01AI121080 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2016 to 2026
$4.6M
Ezh2 regulates follicular helper T cell differentiationR01AI139874 · NIAID · UNIVERSITY OF IOWA · PI PENG, WEIQUN, XUE, HAI-HUI · 2018 to 2022
$2.4M
Targeting Tcf/Lef-transcriptional program in leukemic stem cellsI01BX002903 · VA · VA NEW JERSEY HEALTH CARE SYSTEM · PI XUE, HAI-HUI · 2016 to 2019
–
BLRD VA I01 BX002903NIAID NIH HHS R01 AI112579NIAID NIH HHS R01 AI121080NIAID NIH HHS R01 AI139874NIDDK NIH HHS P30 DK026687U.S. Department of Veterans Affairs BX002903
6 · The paper itself

Abstract

The β-catenin transcriptional coregulator is involved in various biological and pathological processes; however, its requirements in hematopoietic cells remain controversial. We re-targeted the

Indexed as

beta Cateningamma CateninLeukemiaNeoplastic Stem CellsT-Lymphocytesbeta CateninCTNNB1 protein, mousegamma CateninJup protein, mouseacute myeloid leukemiabeta-cateningamma-cateninimmunologyinflammationleukemic stem cellsmouseregenerative medicinestem cellsTcf/LefT lymphocytes

Identifiers

PMID32820720
PMCPMC7462606
OpenAlexW3080115425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.