ArticleAddiction biology2021
Glutamatergic input from the insula to the ventral bed nucleus of the stria terminalis controls reward-related behavior.
Article in Addiction biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Sex differences in insular cortex function in persistent alcohol drinking despite aversion in mice.Molecular psychiatry · 2026Article
- CRH neurons in the dorsal bed nucleus of the stria terminalis (dBNST) mediate contextual fear generalization.Neurobiology of stress · 2026Article
- Comparative insights into insula structure and function.Nature neuroscience · 2026Review
- Dissociable control of depression and visceral pain by the pICNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Bed nucleus of the stria terminalis connectivity during food cue and taste processing under stress.Nature communications · 2026Article
- Regulation of addiction by the insular cortex: The interplay between interoception and cognitive function.iScience · 2025Review
- Opposite-sex pairing alters social-induced GCaMP and dopamine activity in the insula of male prairie voles.Annals of the New York Academy of Sciences · 2025Article
- Insula→Amygdala and Insula→Thalamus Pathways Are Involved in Comorbid Chronic Pain and Depression-Like Behavior in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Chemogenetic Modulation of Posterior Insula CaMKIIa Neurons Alters Pain and Thermoregulation.The journal of pain · 2024Article
- Reduced menthol sensitivity in a prodromal Parkinson's disease model induced by intranasal rotenone treatment.Frontiers in cellular neuroscience · 2024Article
- Mesolimbic dopamine release precedes actively sought aversive stimuli in mice.Nature communications · 2023Article
- Site-Specific Regulation of Stress Responses Along the Rostrocaudal Axis of the Insular Cortex in Rats.Frontiers in neuroscience · 2022Article
- Cellular activity in insular cortex across seconds to hours: Sensations and predictions of bodily states.Neuron · 2021Review
- Better living through understanding the insula: Why subregions can make all the difference.Neuropharmacology · 2021Review
- Binge ethanol drinking associated with sex-dependent plasticity of neurons in the insula that project to the bed nucleus of the stria terminalis.Neuropharmacology · 2021Article
- Extended Amygdala Neuropeptide Circuitry of Emotional Arousal: Waking Up on the Wrong Side of the Bed Nuclei of Stria Terminalis.Frontiers in behavioral neuroscience · 2021Article
- Dorsal Bed Nucleus of the Stria Terminalis-Subcortical Output Circuits Encode Positive Bias in Pavlovian Fear and Reward.Frontiers in neural circuits · 2021Article
- Decreased temporal variabilities of functional connectivities in insula and lingual gyrus are associated with better early treatment response in patients with panic disorder.Journal of psychiatry & neuroscience : JPNArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Individuals suffering from substance use disorder often experience relapse events that are attributed to drug craving. Insular cortex (IC) function is implicated in processing drug-predictive cues and is thought to be a critical substrate for drug craving, but the downstream neural circuit effectors of the IC that mediate reward processing are poorly described. Here, we uncover the functional connectivity of an IC projection to the ventral bed nucleus of the stria terminalis (vBNST), a portion of the extended amygdala that has been previously shown to modulate dopaminergic activity within the ventral tegmental area (VTA), and investigate the role of this pathway in reward-related behaviors. We utilized ex vivo slice electrophysiology and in vivo optogenetics to examine the functional connectivity of the IC-vBNST projection and bidirectionally control IC-vBNST terminals in various reward-related behavioral paradigms. We hypothesized that the IC recruits mesolimbic dopamine signaling by activating VTA-projecting, vBNST neurons. Using slice electrophysiology, we found that the IC sends a glutamatergic projection onto vBNST-VTA neurons. Photoactivation of IC-vBNST terminals was sufficient to reinforce behavior in a dopamine-dependent manner. Moreover, silencing the IC-vBNST projection was aversive and resulted in anxiety-like behavior without affecting food consumption. This work provides a potential mechanism by which the IC processes exteroceptive triggers that are predictive of reward.
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