Evidence map›Paper›PMID 32820572›Full record

ArticleMagnetic resonance in medicine2021

Recovery kinetics of creatine in mild plantar flexion exercise using 3D creatine CEST imaging at 7 Tesla.

Dushyant Kumar, Ravi Prakash Reddy Nanga, Deepa Thakuri, Neil Wilson, Abigail Cember, Melissa Lynne Martin, Dan Zhu, Russell T Shinohara, Qin Qin, Hari Hariharan and 1 more

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Quantitative Assessment of Peripheral Oxidative Metabolism With a New DynamicJournal of magnetic resonance imaging : JMRI · 2024
    Article
  7. Article
  8. The exchange rate of creatine CEST in mouse brain.Magnetic resonance in medicine · 2023
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Dushyant KumarDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-1617-6399
Ravi Prakash Reddy NangaDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Deepa ThakuriDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Neil WilsonSiemens Medical Solutions USA Inc., Malvern, Pennsylvania, USA.
Abigail CemberDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-4747-6079
Melissa Lynne MartinPenn Statistics in Imaging and Visualization Center, Department of Biostatistics and Epidemiology, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Dan ZhuDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Russell T ShinoharaPenn Statistics in Imaging and Visualization Center, Department of Biostatistics and Epidemiology, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Qin QinThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-6432-2944
Hari HariharanDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ravinder ReddyDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
University of Pennsylvania · USPenn Center for AIDS Research · USJohns Hopkins University · USKennedy Krieger Institute · US

Funding

Training and DisseminationP41EB015893 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI REDDY, RAVINDER · 2012 to 2019
$11.3M
High Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in HumansP41EB029460 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Ravinder Reddy · 2021 to 2026
$7.6M
In vivo Mapping of Muscle Specific MetabolismR01AG071725 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Ravinder Reddy · 2022 to 2026
$3.1M
CrCEST MRI of Skeletal Muscle MetabolismR56AG062665 · NIA · UNIVERSITY OF PENNSYLVANIA · PI REDDY, RAVINDER · 2019 to 2019
$656k
NIA NIH HHS R01 AG071725NIA NIH HHS R56 AG062665NIBIB NIH HHS P41 EB015893NIBIB NIH HHS P41 EB029460
6 · The paper itself

Abstract

purposeTwo-dimensional creatine CEST (2D-CrCEST), with a slice thickness of 10-20 mm and temporal resolution (τ

methodsThe current 7T study with enrollment of 5 volunteers involved collecting the baseline CrCEST imaging for the first 2 minutes, followed by 2 minutes of plantar flexion exercise and then 8 minutes of postexercise CrCEST imaging, to detect the temporal evolution of creatine concentration following exercise.

resultsVery good repeatability of 3D-CrCEST findings for activated muscle groups on an intraday and interday basis was established, with coefficient of variance of creatine recovery constants (τ

conclusionIn this study, we demonstrated for the first time the feasibility and the repeatability of the 3D-CrCEST method in calf muscle with improved

Indexed as

CreatineMagnetic Resonance ImagingExerciseHumansKineticsMuscle, SkeletalCreatinecreatinecreatine CESTcreatine kinasecreatine recovery kineticsphosphocreatineplantar flexion exercise

Identifiers

PMID32820572
PMCPMC7774507
OpenAlexW3049515266

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.