Evidence map›Paper›PMID 32820466›Full record

ReviewCanadian journal of anaesthesia = Journal canadien d'anesthesie2020

Efficacy of topical agents for prevention of postoperative sore throat after single lumen tracheal intubation: a Bayesian network meta-analysis.

Narinder P Singh, Jeetinder K Makkar, Ron B Cappellani, Ashish Sinha, Anand Lakshminarasimhachar, Preet Mohinder Singh

Erratum issuedOpen access · bronzeAbstract readReviewNetwork Meta-Analysis
PubMed Publisher
In one paragraph

Review in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Narinder P SinghDepartment of Anesthesia, Perioperative and Pain Medicine, University of Manitoba, Winnipeg, MB, Canada.
Jeetinder K MakkarDepartment of Anaesthesia and Intensive Care, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India. jeet1516@gmail.com.ORCID http://orcid.org/0000-0001-8159-5920
Ron B CappellaniDepartment of Anesthesia, Perioperative and Pain Medicine, University of Manitoba, Winnipeg, MB, Canada.
Ashish SinhaUniversity of California, Riverside/Riverside Community Hospital, Riverside, CA, USA.
Anand LakshminarasimhacharDepartment of Anesthesia, Washington University in Saint Louis, Saint Louis, MO, USA.
Preet Mohinder SinghDepartment of Anesthesia, Washington University in Saint Louis, Saint Louis, MO, USA.
University of Manitoba · CAWashington University in St. Louis · USPost Graduate Institute of Medical Education and Research · INUniversity of California, Riverside · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe optimal choice of prophylactic drugs to decrease postoperative sore throat is unclear. The objective of this network meta-analysis (NMA) was to compare and rank 11 topical agents used to prevent postoperative sore throat.

methodsVarious databases were searched independently for randomized-controlled trials (RCTs) comparing topical agents used for the prevention of postoperative sore throat. Inclusion criteria were parallel group studies comparing intervention with active or inactive control and reporting postoperative sore throat. The primary outcome was postoperative sore throat at 24 hr. Secondary outcomes were early sore throat at 4-6 hr, cough, and hoarseness at 24 hr.

resultsEvidence was synthesized from 70 RCTs reporting 7,141 patients. Topical application of lidocaine, corticosteroids, ketamine, magnesium, benzydamine, water-based lubricant, and liquorice applied along the tracheal tube, to the tracheal tube cuff, gargled or sprayed were compared with intracuff air and each other. Bayesian NMA showed that magnesium (odds ratio [OR], 0.10; 95% credible interval [CrI], 0.03 to 0.26), liquorice (OR, 0.14; 95% CrI, 0.03 to 0.55), and steroid application (OR, 0.11; 95% CrI, 0.06 to 0.22) most effectively prevented postoperative sore throat at 24 hr. Topical lidocaine was the least effective intervention.

conclusionTopical application of magnesium followed by liquorice and corticosteroids most effectively prevented postoperative sore throat 24 hr after endotracheal intubation.

Indexed as

BenzydaminePharyngitisHumansIntubation, IntratrachealPostoperative ComplicationsBenzydamineCoughHoarsenessPostoperative sore throat prophylaxistopical agenttracheal tube

Identifiers

PMID32820466
OpenAlexW3195411676

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.