Evidence map›Paper›PMID 32820460›Full record

ArticleMolecular neurobiology2020

Layers II/III of Prefrontal Cortex in Df(h22q11)/+ Mouse Model of the 22q11.2 Deletion Display Loss of Parvalbumin Interneurons and Modulation of Neuronal Morphology and Excitability.

Abdel-Rahman Al-Absi, Per Qvist, Samora Okujeni, Ahmad Raza Khan, Simon Glerup, Connie Sanchez, Jens R Nyengaard

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Prefrontal Interneurons: Populations, Pathways, and Plasticity Supporting Typical and Disordered Cognition in Rodent Models.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Abdel-Rahman Al-AbsiCentre for Molecular Morphology, Section for Stereology and Microscopy; Centre for Stochastic Geometry and Advanced Bioimaging, Department of Clinical Medicine, Aarhus University, Palle Juul Jensens Boulevard, 99 8200, Aarhus N, Denmark. abd.alabsi@clin.au.dk.ORCID http://orcid.org/0000-0002-4176-6630
Per QvistDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Samora OkujeniLaboratory for Biomicrotechnology, Department of Microsystems Engineering IMTEK, University of Freiburg, Freiburg, Germany.
Ahmad Raza KhanCenter of Functionally Integrative Neuroscience (CFIN), Aarhus University, Aarhus, Denmark.
Simon GlerupDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Connie SanchezTranslational Neuropsychiatry Unit, Aarhus University, Aarhus, Denmark.
Jens R NyengaardCentre for Molecular Morphology, Section for Stereology and Microscopy; Centre for Stochastic Geometry and Advanced Bioimaging, Department of Clinical Medicine, Aarhus University, Palle Juul Jensens Boulevard, 99 8200, Aarhus N, Denmark.
Aarhus University · DKSanjay Gandhi Post Graduate Institute of Medical Sciences · INUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The 22q11.2 deletion has been identified as a risk factor for multiple neurodevelopmental disorders. Behavioral and cognitive impairments are common among carriers of the 22q11.2 deletion. Parvalbumin expressing (PV

Indexed as

Cell ShapeAnimalsBicucullineDiGeorge SyndromeDisease Models, AnimalDisks Large Homolog 4 ProteinGABA-A Receptor AntagonistsInterneuronsMaleMiceParvalbuminsPrefrontal CortexProtein SubunitsPyramidal CellsReceptors, GABA-ARNA, MessengerBicucullineDisks Large Homolog 4 ProteinGABA-A Receptor AntagonistsParvalbuminsProtein SubunitsReceptors, GABA-ARNA, MessengerDf(h22q11)/+ mouse modelGABAA (α3) receptor subunitParvalbumin interneuronsPrefrontal cortexPyramidal neurons

Identifiers

PMID32820460
OpenAlexW3080989783

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.