Evidence map›Paper›PMID 32820352›Full record

ArticleApplied biochemistry and biotechnology2021

Overproduction of Exopolysaccharide Colanic Acid by Escherichia coli by Strain Engineering and Media Optimization.

Hyeong Min Han, In Jung Kim, Eun Ju Yun, Jae Won Lee, Yoonho Cho, Yong-Su Jin, Kyoung Heon Kim

Abstract read
PubMed Publisher
In one paragraph

Article in Applied biochemistry and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. A deformableMaterials today. Bio · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hyeong Min HanDepartment of Biotechnology, Korea University Graduate School, Seoul, 02841, South Korea.
In Jung KimDepartment of Biotechnology, Korea University Graduate School, Seoul, 02841, South Korea.
Eun Ju YunDepartment of Biotechnology, Korea University Graduate School, Seoul, 02841, South Korea.
Jae Won LeeDepartment of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Yoonho ChoDepartment of Biotechnology, Korea University Graduate School, Seoul, 02841, South Korea.
Yong-Su JinDepartment of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. ysjin@illinois.edu.
Kyoung Heon KimDepartment of Biotechnology, Korea University Graduate School, Seoul, 02841, South Korea. khekim@korea.ac.kr.ORCID http://orcid.org/0000-0003-4600-8668

Funding

National Research of Korea 2020R1A2B5B02002631Research Fellow Program through NRF 2017R1A6A3A11030496
6 · The paper itself

Abstract

Colanic acid (CA) is one of the major bacterial exopolysaccharides. Due to its biological activities, CA has a significant commercial value. However, the cultivation conditions have not been optimized for the large-scale production of CA. Here, we constructed a CA-overproducing Escherichia coli strain (ΔwaaF) and statistically optimized its culture media for maximum CA production. Glucose and tryptone were found the optimal carbon and nitrogen sources, respectively. Fractional factorial design indicated tryptone and Na

Indexed as

Escherichia coliMetabolic EngineeringMicroorganisms, Genetically-ModifiedPolysaccharidescolanic acidPolysaccharidesColanic acidEscherichia coli ΔwaaFExopolysaccharideFractional factorial designMedia optimizationResponse surface methodologySteepest ascent method

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.