Evidence map›Paper›PMID 32820248›Full record

ReviewMucosal immunology2020

Animal and translational models of SARS-CoV-2 infection and COVID-19.

M D Johansen, A Irving, X Montagutelli, M D Tate, I Rudloff, M F Nold, N G Hansbro, R Y Kim, C Donovan, G Liu and 19 more

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Mucosal immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 2 syntheses or guidelines pooled it, 190 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Article
  7. Ex vivo functional whole organ in biomedical research: a review.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025
    Review
  8. Article
  9. Integrated genomic and proteomic analysis of the mouse-adaptedCurrent research in microbial sciences · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Medicina (Kaunas, Lithuania) · 2023
    Article
  17. Article
  18. Review
  19. Article
  20. The Complex Association between COPD and COVID-19.Journal of clinical medicine · 2023
    Review

61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 7 institutions in 3 countries.

M D JohansenCentre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, Sydney, Australia.
A IrvingZhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, ZJU International Campus, Haining, China.
X MontagutelliDepartment of Genomes and Genetics, Institut Pasteur, Paris, France.
M D TateCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.
I RudloffRitchie Centre, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.
M F NoldRitchie Centre, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.
N G HansbroCentre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, Sydney, Australia.
R Y KimCentre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, Sydney, Australia.
C DonovanCentre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, Sydney, Australia.
G LiuCentre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, Sydney, Australia.
A FaizCentre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, Sydney, Australia.
K R ShortSchool of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Australia.
J G LyonsCentenary Institute and Dermatology, The University of Sydney and Cancer Services, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
G W McCaughanCentenary Institute and Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
M D GorrellCentenary Institute and Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
A ColeCentenary Institute and Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
C MorenoDr. John and Anne Chong Lab for Functional Genomics, Charles Perkins Centre, Centenary Institute, and School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, Australia.
D CouteurCharles Perkins Centre and School of Life and Environmental Sciences, University of Sydney, and Faculty of Medicine and Health, Concord Clinical School, ANZAC Research Institute and Centre for Education and Research on Ageing, Sydney, Australia.
D HesselsonCentenary Institute and Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
J TriccasDiscipline of Infectious Diseases and Immunology, Central Clinical School, Faculty of Medicine and Health and the Charles Perkins Centre, The University of Sydney, Camperdown, Sydney, Australia.
G G NeelyDr. John and Anne Chong Lab for Functional Genomics, Charles Perkins Centre, Centenary Institute, and School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, Australia.
J R GambleCentenary Institute and Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
S J SimpsonCharles Perkins Centre and School of Life and Environmental Sciences, University of Sydney, and Faculty of Medicine and Health, Concord Clinical School, ANZAC Research Institute and Centre for Education and Research on Ageing, Sydney, Australia.
B M SaundersCentre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, Sydney, Australia.
B G OliverCentre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, Sydney, Australia.
W J BrittonCentenary Institute, The University of Sydney and Department of Clinical Immunology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
P A WarkPriority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW, Australia.
C A Nold-PetryDepartment of Molecular and Translational Sciences, Monash University, Clayton, VIC, Australia.
P M HansbroCentre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, Sydney, Australia. Philip.Hansbro@uts.edu.au.ORCID http://orcid.org/0000-0002-4741-3035
The University of Sydney · AUUniversity of Technology Sydney · AUHudson Institute of Medical Research · AUHunter Medical Research Institute · AUInstitut Pasteur · FRSecond Affiliated Hospital of Zhejiang University · CNThe University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 is causing a major once-in-a-century global pandemic. The scientific and clinical community is in a race to define and develop effective preventions and treatments. The major features of disease are described but clinical trials have been hampered by competing interests, small scale, lack of defined patient cohorts and defined readouts. What is needed now is head-to-head comparison of existing drugs, testing of safety including in the background of predisposing chronic diseases, and the development of new and targeted preventions and treatments. This is most efficiently achieved using representative animal models of primary infection including in the background of chronic disease with validation of findings in primary human cells and tissues. We explore and discuss the diverse animal, cell and tissue models that are being used and developed and collectively recapitulate many critical aspects of disease manifestation in humans to develop and test new preventions and treatments.

Indexed as

Disease Models, AnimalAngiotensin-Converting Enzyme 2AnimalsAnimals, Genetically ModifiedAntibodies, ViralAntiviral AgentsBetacoronavirusCatsChiropteraCoronavirus InfectionsCOVID-19COVID-19 VaccinesCricetulusFemaleFerretsHaplorhiniACE2 protein, humanAce2 protein, mouseAngiotensin-Converting Enzyme 2Antibodies, ViralAntiviral AgentsCOVID-19 VaccinesPeptidyl-Dipeptidase ASpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Viral Vaccines

Identifiers

PMID32820248
PMCPMC7439637
OpenAlexW3063771132

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.