Evidence map›Paper›PMID 32820163›Full record

ReviewNature reviews. Disease primers2020

Comorbid depression in medical diseases.

Stefan M Gold, Ole Köhler-Forsberg, Rona Moss-Morris, Anja Mehnert, J Jaime Miranda, Monika Bullinger, Andrew Steptoe, Mary A Whooley, Christian Otte

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Disease primers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06765057 (Effect of Probiotics "Psychobiotics" on Depression in Adults With Pre-Metabolic Syndrome and Metabolic Syndrome in Riyadh City), which is not on this map. Cited by 283 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
283citing papers in PubMed, 16 pooled it
35.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06765057 phase2 / phase3recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Probiotics "Psychobiotics" on Depression in Adults With Pre-Metabolic Syndrome and Metabolic Syndrome in Riyadh City

TypeinterventionalSponsorRoaa Ahmed AlkreadeesRan2025 to 2027Enrolled60ConditionsDepression Anxiety DisorderArmsWinclove's Ecologic® Barrier Probiotics, Winclove's Ecologic® Barrier Probiotics Placebo
3 · Its place in the literature

Who cites it

283 citing papers in PubMed, 16 syntheses or guidelines pooled it, 493 citations in OpenAlex.

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223 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 5 countries.

Stefan M GoldCharité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt Universität zu Berlin, Berlin Institute of Health (BIH), Klinik für Psychiatrie und Psychotherapie, Campus Benjamin Franklin, Berlin, Germany. stefan.gold@charite.de.
Ole Köhler-ForsbergDepartment for Affective Disorders, Aarhus University Hospital - Psychiatry, Aarhus, Denmark.
Rona Moss-MorrisPsychology Department, Institute of Psychology, Psychiatry and Neuroscience, King's College London (KCL), Guy's Hospital Campus, London Bridge, London, UK.
Anja MehnertAbteilung für Medizinische Psychologie und Medizinische Soziologie, Universitätsklinikum Leipzig, Leipzig, Germany.
J Jaime MirandaCRONICAS Centre of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.
Monika BullingerInstitut und Poliklinik für Medizinische Psychologie, Unversitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
Andrew SteptoeDepartment of Behavioural Science and Health, University College London, London, UK.
Mary A WhooleyUniversity of California, San Francisco (UCSF), San Francisco VA Health Care System, San Francisco, CA, USA.
Christian OtteCharité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt Universität zu Berlin, Berlin Institute of Health (BIH), Klinik für Psychiatrie und Psychotherapie, Campus Benjamin Franklin, Berlin, Germany.
Freie Universität Berlin · DEAarhus University · DKGuy's Hospital · GBUniversidad Peruana Cayetano Heredia · PEUniversität Hamburg · DEUniversity College London · GBUniversity Hospital Leipzig · DEUniversity of California, San Francisco · US

Funding

Household Air Pollution and Health: A Multi-Country LPG Intervention TrialUM1HL134590 · NHLBI · EMORY UNIVERSITY · PI CHECKLEY, WILLIAM, CLASEN, THOMAS F · 2016 to 2021
$31.1M
Latin America Treatment & Innovation Network in Mental Health (LATIN-MH)U19MH098780 · NIMH · FUNDACAO FACULDADE DE MEDICINA · PI ARAYA, RICARDO, MENEZES, PAULO ROSSI · 2013 to 2017
$2.7M
Launching a salt substitute to reduce blood pressure at the population level-PeruU01HL114180 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI GILMAN, ROBERT H · 2012 to 2016
$2.0M
Building sustainable and innovative research in Cancer and Cardiovascular disease: Planning the design and development of the South American Center of Research Excellence to Counter NCDs (SACREN)P20CA217231 · NCI · INSTITUTO DE EFECTIVIDAD CLINICA Y SANIT · PI IRAZOLA, VILMA, MIRANDA, J JAIME · 2017 to 2018
$497k
Implementation of foot thermometry and SMS to prevent diabetic foot ulcerR21TW009982 · FIC · UNIVERSIDAD PERUANA CAYETANO HEREDIA · PI MIRANDA, J JAIME · 2014 to 2015
$329k
Planning to Establish a Regional Center of NCD Research Training in PeruD71TW010877 · FIC · UNIVERSIDAD PERUANA CAYETANO HEREDIA · PI MIRANDA, J JAIME · 2017 to 2017
$50k
FIC NIH HHS D71 TW010877FIC NIH HHS R21 TW009982Medical Research Council MR/M007405/1Medical Research Council MR/P008984/1Medical Research Council MR/P02386X/1Medical Research Council MR/P024408/1NCI NIH HHS P20 CA217231NHLBI NIH HHS HHSN268200900033CNHLBI NIH HHS U01 HL114180NHLBI NIH HHS UM1 HL134590NIMH NIH HHS U19 MH098780Wellcome Trust 074833/Z/04/ZWellcome Trust 093541/Z/10/ZWellcome Trust 103994/Z/14/ZWellcome Trust 107435/Z/15/ZWellcome Trust 205177/Z/16/ZWellcome Trust 214185/Z/18/ZWellcome Trust 218743/Z/19/Z
6 · The paper itself

Abstract

Depression is one of the most common comorbidities of many chronic medical diseases including cancer and cardiovascular, metabolic, inflammatory and neurological disorders. Indeed, the prevalence of depression in these patient groups is often substantially higher than in the general population, and depression accounts for a substantial part of the psychosocial burden of these disorders. Many factors can contribute to the occurrence of comorbid depression, such as shared genetic factors, converging biological pathways, social factors, health behaviours and psychological factors. Diagnosis of depression in patients with a medical disorder can be particularly challenging owing to symptomatic overlap. Although pharmacological and psychological treatments can be effective, adjustments may need to be made for patients with a comorbid medical disorder. In addition, symptoms or treatments of medical disorders may interfere with the treatment of depression. Conversely, symptoms of depression may decrease adherence to treatment of both disorders. Thus, comprehensive treatment plans are necessary to optimize care.

Indexed as

ComorbidityAdaptation, PsychologicalChronic DiseaseDepressionHumansPrevalence

Identifiers

PMID32820163
OpenAlexW3075884737

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.