Evidence map›Paper›PMID 32820145›Full record

ArticleCell death & disease2020

Shedding of cancer susceptibility candidate 4 by the convertases PC7/furin unravels a novel secretory protein implicated in cancer progression.

Stéphanie Duval, Afnan Abu-Thuraia, Islam E Elkholi, Rui Chen, Deeptee Seebun, Janice Mayne, Jean-François Côté, Daniel Figeys, Nabil G Seidah

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  3. Monensin suppresses EMT-driven cancer cell motility by inducing Golgi pH-dependent exocytosis of GOLIM4.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Stéphanie DuvalLaboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM; Affiliated to the University of Montreal), 110 Pine Ave West, Montreal, QC, H2W1R7, Canada.
Afnan Abu-ThuraiaLaboratory of Cytoskeletal Organization and Cell Migration, Montreal Clinical Research Institute (IRCM; affiliated to the University of Montreal), 110 Pine Ave West, Montreal, QC, H2W1R7, Canada.
Islam E ElkholiLaboratory of Cytoskeletal Organization and Cell Migration, Montreal Clinical Research Institute (IRCM; affiliated to the University of Montreal), 110 Pine Ave West, Montreal, QC, H2W1R7, Canada.
Rui ChenOttawa Institute of Systems Biology and Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.
Deeptee SeebunOttawa Institute of Systems Biology and Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.
Janice MayneOttawa Institute of Systems Biology and Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.
Jean-François CôtéLaboratory of Cytoskeletal Organization and Cell Migration, Montreal Clinical Research Institute (IRCM; affiliated to the University of Montreal), 110 Pine Ave West, Montreal, QC, H2W1R7, Canada.ORCID http://orcid.org/0000-0001-7055-2642
Daniel FigeysOttawa Institute of Systems Biology and Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.
Nabil G SeidahLaboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM; Affiliated to the University of Montreal), 110 Pine Ave West, Montreal, QC, H2W1R7, Canada. seidahn@ircm.qc.ca.ORCID http://orcid.org/0000-0001-6503-9342
Montreal Clinical Research Institute · CAUniversity of Ottawa · CA

Funding

CIHR 148363CIHR MOP-142425
6 · The paper itself

Abstract

The proprotein convertases (PCs) are responsible for the maturation of precursor proteins, and are involved in multiple and critical biological processes. Over the past 30 years, the PCs have had great translational applications, but the physiological roles of PC7, the seventh member of the family, are still obscure. Searching for new substrates of PC7, a quantitative proteomics screen for selective enrichment of N-glycosylated polypeptides secreted from hepatic HuH7 cells identified two human type-II transmembrane proteins of unknown function(s): Cancer Susceptibility Candidate 4 (CASC4) and Golgi Phosphoprotein of 130 kDa (GPP130/GOLIM4). Concentrating on CASC4, its mutagenesis characterized the PC7/Furin-shedding site to occur at KR

Indexed as

Amino Acid SequenceCell Line, TumorDisease ProgressionEndosomesFurinHEK293 CellsHepatocytesHumansNeoplasm ProteinsProprotein ConvertasesProtein Processing, Post-TranslationalProtein TransportProteomicsSubtilisinsTriple Negative Breast NeoplasmsTumor Suppressor ProteinsFurinFURIN protein, humanNeoplasm ProteinsPCSK7 protein, humanproprotein convertase PC7Proprotein ConvertasesSubtilisinsTumor Suppressor Proteins

Identifiers

PMID32820145
PMCPMC7441151
OpenAlexW3068150758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.