Evidence map›Paper›PMID 32820061›Full record

ArticleScience (New York, N.Y.)2020

Structural basis of transcription-translation coupling.

Chengyuan Wang, Vadim Molodtsov, Emre Firlar, Jason T Kaelber, Gregor Blaha, Min Su, Richard H Ebright

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 151 citations in OpenAlex.

  1. Exchange dynamics and kinetic control of gene regulation complexes.Nature reviews. Molecular cell biology · 2026
    Review
  2. RfaH licenses RNA polymerase for long-range transcription.bioRxiv : the preprint server for biology · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Structural basis of long-range transcription-translation coupling.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
  8. Structural principles of transcriptional collisions.bioRxiv : the preprint server for biology · 2026
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. mBio · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Chengyuan Wang *Waksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA.ORCID 0000-0002-8605-0716
Vadim Molodtsov *Waksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA.ORCID 0000-0003-3002-4794
Emre FirlarRutgers New Jersey CryoEM/CryoET Core Facility and Institute for Quantitative Biomedicine, Rutgers University, Piscataway, NJ 08854, USA.ORCID 0000-0003-0190-6528
Jason T KaelberRutgers New Jersey CryoEM/CryoET Core Facility and Institute for Quantitative Biomedicine, Rutgers University, Piscataway, NJ 08854, USA.ORCID 0000-0001-9426-1030
Gregor BlahaDepartment of Biochemistry, University of California, Riverside, CA 92521, USA.ORCID 0000-0001-7228-0185
Min SuLife Sciences Institute, University of Michigan, Ann Arbor, MI,48109, USA. minsu@umich.edu ebright@waksman.rutgers.edu.ORCID 0000-0002-0561-906X
Richard H EbrightWaksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA. minsu@umich.edu ebright@waksman.rutgers.edu.ORCID 0000-0001-8915-7140
Rutgers, The State University of New Jersey · USEnvironmental Research Institute of Michigan · USUniversity of California, Riverside · US

Funding

Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8M
NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9M
TRANSCRIPTION ACTIVATION BY CAPR01GM041376 · NIGMS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI RICHARD H. EBRIGHT · 1989 to 2026
$6.5M
BACTERIAL TRANSCRIPTION COMPLEXESR37GM041376 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI EBRIGHT, RICHARD H. · 2013 to 2022
$5.0M
NIGMS NIH HHS R01 GM041376NIGMS NIH HHS R37 GM041376NIGMS NIH HHS U24 GM129539NIGMS NIH HHS U24 GM129547
6 · The paper itself

Abstract

In bacteria, transcription and translation are coupled processes in which the movement of RNA polymerase (RNAP)-synthesizing messenger RNA (mRNA) is coordinated with the movement of the first ribosome-translating mRNA. Coupling is modulated by the transcription factors NusG (which is thought to bridge RNAP and the ribosome) and NusA. Here, we report cryo-electron microscopy structures of

Indexed as

Protein BiosynthesisTranscription, GeneticCryoelectron MicroscopyDNA-Directed RNA PolymerasesEscherichia coliEscherichia coli ProteinsGene Expression Regulation, BacterialPeptide Elongation FactorsProtein BindingProtein ConformationRNA, MessengerTranscriptional Elongation FactorsTranscription FactorsDNA-Directed RNA PolymerasesEscherichia coli ProteinsnusA protein, E coliNusG protein, E coliPeptide Elongation FactorsRNA, MessengerTranscriptional Elongation FactorsTranscription Factors

Identifiers

PMID32820061
PMCPMC7566311
OpenAlexW3080720382

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.