Evidence map›Paper›PMID 32820022›Full record

ArticleDevelopment (Cambridge, England)2020

Loss of the seipin gene perturbs eggshell formation in

Xiaofei Bai, Leng-Jie Huang, Sheng-Wen Chen, Benjamin Nebenfuehr, Brian Wysolmerski, Jui-Ching Wu, Sara K Olson, Andy Golden, Chao-Wen Wang

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 28 citations in OpenAlex.

  1. Quantifying Embryonic Lethality Rate in Caenorhabditis elegans.Journal of visualized experiments : JoVE · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
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  10. The evolving landscape of ER-LD contact sites.Frontiers in cell and developmental biology · 2024
    Review
  11. Concept of lipid droplet biogenesis.European journal of cell biology · 2023
    Review
  12. Review
  13. Application ofInternational journal of molecular sciences · 2023
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Xiaofei BaiLaboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Leng-Jie HuangInstitute of Plant and Microbial Biology, Academia Sinica, Nankang, Taipei 11529, Taiwan.
Sheng-Wen ChenInstitute of Plant and Microbial Biology, Academia Sinica, Nankang, Taipei 11529, Taiwan.
Benjamin NebenfuehrLaboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Brian WysolmerskiDepartment of Biology and Program in Molecular Biology, Pomona College, Claremont, CA 91711, USA.
Jui-Ching WuDepartment of Clinical Laboratory Science and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei 10048, Taiwan.
Sara K OlsonDepartment of Biology and Program in Molecular Biology, Pomona College, Claremont, CA 91711, USA.
Andy GoldenLaboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-8599-2031
Chao-Wen WangInstitute of Plant and Microbial Biology, Academia Sinica, Nankang, Taipei 11529, Taiwan cwwang02@gate.sinica.edu.tw.ORCID 0000-0002-4073-299X
Institute of Plant and Microbial Biology, Academia Sinica · TWNational Institutes of Health · USPomona College · USNational Taiwan University · TW

Funding

The Investigation of disease causing genes in C. elegansZIADK075075 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI GOLDEN, ANDY · 2012 to 2023
$9.0M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Seipin, an evolutionary conserved protein, plays pivotal roles during lipid droplet (LD) biogenesis and is associated with various human diseases with unclear mechanisms. Here, we analyzed

Indexed as

Genes, HelminthAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsDietary SupplementsDisease Models, AnimalEgg ShellEmbryo, NonmammalianFatty Acids, UnsaturatedFertilizationGene DeletionGene Expression Regulation, DevelopmentalHumansLipid DropletsLipidomicsMembrane ProteinsCaenorhabditis elegans ProteinsFatty Acids, UnsaturatedMembrane Proteinsseip-1 protein, C elegansEggshellFatty acidLipid dropletPermeability barrierPUFAsSeipin

Identifiers

PMID32820022
PMCPMC7578359
OpenAlexW3053086198

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.