Evidence map›Paper›PMID 32819827›Full record

ReviewTrends in parasitology2020

Immunometabolism in Arthropod Vectors: Redefining Interspecies Relationships.

Sourabh Samaddar, Liron Marnin, L Rainer Butler, Joao H F Pedra

Abstract readReview
In one paragraph

Review in Trends in parasitology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. ATF6 enables pathogen infection in ticks by inducingProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Review
  6. Rewiring the Vehicle:Ecology and evolution · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Ticks: More Than Just a Pathogen Delivery Service.Frontiers in cellular and infection microbiology · 2021
    Article
  15. Review
  16. Trained Immunity inFrontiers in microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sourabh SamaddarDepartment of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, MD, USA.
Liron MarninDepartment of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, MD, USA.
L Rainer ButlerDepartment of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, MD, USA.
Joao H F PedraDepartment of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, MD, USA. Electronic address: jpedra@som.umaryland.edu.

Funding

Tick Resources CoreP01AI138949 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI Erol Fikrig, UTPAL PAL · 2018 to 2026
$13.5M
Development of Paratransgenic Ticks for Disease ControlR01AI049424 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MUNDERLOH, ULRIKE GERTRUD · 2002 to 2022
$6.9M
Ubiquitylation and Rickettsial Colonization of a Tick VectorR01AI116523 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PEDRA, JOAO · 2016 to 2025
$6.2M
Tick Saliva and Pathogen TransmissionR01AI134696 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Joao Pedra · 2018 to 2026
$5.1M
NIAID NIH HHS P01 AI138949NIAID NIH HHS R01 AI049424NIAID NIH HHS R01 AI116523NIAID NIH HHS R01 AI134696
6 · The paper itself

Abstract

Metabolism influences biochemical networks, and arthropod vectors are endowed with an immune system that affects microbial acquisition, persistence, and transmission to humans and other animals. Here, we aim to persuade the scientific community to expand their interests in immunometabolism beyond mammalian hosts and towards arthropod vectors. Immunometabolism investigates the interplay of metabolism and immunology. We provide a conceptual framework for investigators from diverse disciplines and indicate that relationships between microbes, mammalian hosts and their hematophagous arthropods may result in cost-effective (mutualism) or energetically expensive (parasitism) interactions. We argue that disparate resource allocations between species may partially explain why some microbes act as pathogens when infecting humans and behave as mutualistic or commensal organisms when colonizing arthropod vectors.

Indexed as

AnimalsArthropodsArthropod VectorsSpecies Specificityarthropod vectorsimmunometabolismmicrobespathogens

Identifiers

PMID32819827
PMCPMC7897511

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.