Evidence map›Paper›PMID 32819433›Full record

ArticleSystematic reviews2020

Genetic determinants of cannabis use: a systematic review protocol.

Alannah Hillmer, Caroul Chawar, Stephanie Sanger, Alessia D'Elia, Mehreen Butt, Raveena Kapoor, Flavio Kapczinski, Guillaume Pare, Lehana Thabane, Zainab Samaan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Systematic reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Chronic adolescent exposure to cannabis in mice leads to sex-biased changes in gene expression networks across brain regions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alannah HillmerNeuroscience Graduate Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, 100 West 5th St., Hamilton, ON, L8N 3 K7, Canada.
Caroul ChawarNeuroscience Graduate Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, 100 West 5th St., Hamilton, ON, L8N 3 K7, Canada.
Stephanie SangerHealth Science Library, McMaster University, 1280 Main St. W, Hamilton, ON, L8S 4 L8, Canada.
Alessia D'EliaNeuroscience Graduate Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, 100 West 5th St., Hamilton, ON, L8N 3 K7, Canada.
Mehreen ButtIntegrated Science Program, McMaster University, 1280 Main St. W, Hamilton, ON, L8S 4 L8, Canada.
Raveena KapoorHealth Sciences Program, McMaster University, 1280 Main St. W, Hamilton, ON, L8S 4 L8, Canada.
Flavio KapczinskiDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, 100 West 5th St., Hamilton, ON, L8N 3 K7, Canada.
Guillaume ParePopulation Health Research Institute, McMaster University, 1280 Main St. W, Hamilton, ON, L8S 4 L8, Canada.
Lehana ThabaneDepartment of Health Research Method, Evidence & Impact, 1280 Main St. W, Hamilton, ON, L8S 4 L8, Canada.
Zainab SamaanDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, 100 West 5th St., Hamilton, ON, L8N 3 K7, Canada. samaanz@mcmaster.ca.ORCID 0000-0002-5974-9361

Funding

CIHR PJT-156306
6 · The paper itself

Abstract

backgroundWith the legalization of cannabis in Canada, there is an increase trend in use. Cannabis has been known to have several health implications, one of which is the development of cannabis use disorder (CUD). CUD is more common in males than females, as well as in certain ethnic groups such as Native Americans. Additionally, both environmental and genetic risk factors have been found for cannabis use. The objective of this systematic review will be to summarize the genetic variants associated with cannabis use which have reached borderline genome-wide significance.

methodsThis systematic review will incorporate articles that have performed a genome-wide association study (GWAS) investigating cannabis use. MEDLINE, Web of Science, EMBASE, GWAS Catalog, GWAS Central, and NIH Database of Genotype and Phenotype will be searched using a comprehensive search strategy. The quality of genetic association studies (Q-Genie) tool will be utilized to assess the quality of the included studies. All screening and data extraction will occur independently by two authors. If feasible, a random-effects meta-analysis will be conducted on pooled odds ratios of single nucleotide polymorphisms reaching borderline genome-wide significance. DISCUSSION: This systematic review will synthesize available GWAS on cannabis use. Results from this review will inform and direct further investigation of genetic variants associated with cannabis use. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42020176016.

Indexed as

CannabisAnalgesicsCanadaGenome-Wide Association StudyMeta-Analysis as TopicSystematic Reviews as TopicAnalgesicsCannabisGeneticsGenome-wideSystematic review

Identifiers

PMID32819433
PMCPMC7441561

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.