ArticleRadiation oncology (London, England)2020
Impact of delays in radiotherapy of head and neck cancer on outcome.
Article in Radiation oncology (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Autonomous radiotherapy planning via agentic orchestration using a multimodal TPS-integrated compound AI platform.Machine learning. Health · 2026Article
- Prediction of Residual Disease in Unresectable Head and Neck Squamous Cell Carcinoma After Concurrent Chemoradiotherapy.World journal of oncology · 2026Article
- Tumor Growth Rate in Head and Neck Squamous Cell Carcinoma: A Scoping Review.Laryngoscope investigative otolaryngology · 2026Review
- The Evolving Role of Radiation Therapy Technologists in Head and Neck Cancer: A Narrative Review and Operational Framework.Journal of imaging · 2026Review
- Simulation-free spine palliative radiotherapy enabled by AI-adapted diagnostic CT.Medical physics · 2026Article
- Reducing delays in radiotherapy initiation post CT simulation: a quality improvement study from a rural cancer center in India.Ecancermedicalscience · 2026Article
- Impact of Postoperative Radiation Therapy Delay and Treatment Facility Location on Survival in Head and Neck Cancer Patients.Head & neck · 2025Article
- Same-Day Access for Head and Neck Cancer: Effect on Patient Outcome and Quality-Related Benchmarks.Journal of patient experience · 2025Article
- Physician barriers and dilemmas in the execution of clinical trials impacting decision-making in the DAHANCA 35 proton therapy trial for head and neck cancer.Technical innovations & patient support in radiation oncology · 2024Article
- Factors Contributing to Postoperative Radiotherapy Delays in Head and Neck Cancer: A Comprehensive Review.Cureus · 2024Review
- Article
- Safety Review of Radiotherapy for Tumor Patients with Implantable Cardiac Pacemaker.Acta Cardiologica Sinica · 2023Review
- Fewer head and neck cancer diagnoses and faster treatment initiation during COVID-19 in 2020: A nationwide population-based analysis.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2022Article
- Resource planning principles for the radiotherapy process using simulations applied to a longer vacation period use case.Technical innovations & patient support in radiation oncology · 2021Article
- Treatment Initiation of Definitive Radiotherapy in Patients With Locally Advanced Head and Neck Cancer.Cancer control : journal of the Moffitt Cancer CenterArticle
- Strategic Reduction of Package Time in Head and Neck Cancer.Advances in radiation oncologyArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundIn head and neck cancer (HNC), the relationship between a delay in starting radiotherapy (RT) and the outcome is unclear. The aim of the present study was to determine the impact of the amount of time before treatment intervention (TTI) and the growth kinetics of individual tumors on treatment outcomes and survival.
methodsTwo hundred sixty-two HNC patients with 273 primary tumors, treated with definitive (chemo) RT, were retrospectively analyzed. The TTI was defined as the time interval between the date of histopathologic diagnosis and the first day of the RT course. Volumetric data on 57 tumors were obtained from diagnostic and RT planning computer tomography (CT) scans in order to calculate the tumor growth kinetic parameters.
resultsNo significant association between locoregional control or cause-specific hazards and TTI was found. The log hazard for locoregional recurrence linearly increased during the first 40 days of waiting for RT, although this was not significant. The median tumor volume relative increase rate and tumor volume doubling time was 3.2%/day and 19 days, respectively, and neither had any impact on locoregional control or cause-specific hazards.
conclusionThe association between a delay in starting RT and the outcome is complex and does not harm all patients waiting for RT. Further research into imaging-derived kinetic data on individual tumors is warranted in order to identify patients at an increased risk of adverse outcomes due to a delay in starting RT.
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