Evidence map›Paper›PMID 32819306›Full record

ArticleBMC cancer2020

Height as a risk factor in meningioma: a study of 2 million Israeli adolescents.

Matan Ben-Zion Berliner, Lior Haim Katz, Estela Derazne, Hagai Levine, Lital Keinan-Boker, Alexandra Benouaich-Amiel, Omer Gal, Andrew A Kanner, Yosef Laviv, Asaf Honig and 4 more

Open access · goldAbstract read
In one paragraph

Article in BMC cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Matan Ben-Zion BerlinerNeuro-Oncology Unit, Davidoff Cancer Center, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel. matanbe4@gmail.com.ORCID https://orcid.org/0000-0001-6089-2467
Lior Haim KatzDepartment of Gastroenterology, Hadassah University Hospital - Ein Kerem, Jerusalem, Israel.
Estela DerazneSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Hagai LevineBraun School of Public Health and Community Medicine, Hadassah University Hospital - Ein Kerem, Jerusalem, Israel.
Lital Keinan-BokerIsrael Center for Disease Control, Israel Ministry of Health, Ramat Gan, Israel.
Alexandra Benouaich-AmielNeuro-Oncology Unit, Davidoff Cancer Center, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel.
Omer GalNeuro-Oncology Unit, Davidoff Cancer Center, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel.
Andrew A KannerSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Yosef LavivSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Asaf HonigMedical Corps, Israel Defense Forces,and Department of Military Medicine, Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem, Israel.
Tali SiegalNeuro-Oncology Unit, Davidoff Cancer Center, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel.
Jacob MandelMedical Corps, Israel Defense Forces,and Department of Military Medicine, Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem, Israel.
Gilad TwigSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Shlomit Yust-KatzNeuro-Oncology Unit, Davidoff Cancer Center, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel.
Tel Aviv University · ILRabin Medical Center · ILHadassah Medical Center · ILHebrew University of Jerusalem · ILIsrael Ministry of Health · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMeningiomas are the most common primary central nervous system tumors. Potential risk factors include obesity, height, history of allergy/atopy, and autoimmune diseases, but findings are conflicting. This study sought to assess the role of the different risk factors in the development of meningioma in adolescents/young adults.

methodsThe cohort included 2,035,915 Jewish men and women who had undergone compulsory physical examination between 1967 and 2011, at age 16 to 19 years, prior to and independent of actual military enlistment. To determine the incidence of meningioma, the military database was matched with the Israel National Cancer Registry. Cox proportional hazard models were used to estimate the hazard ratios for meningioma according to sex, body mass index (BMI), height, and history of allergic or autoimmune disease.

resultsA total of 480 subjects (328 females) were diagnosed with meningioma during a follow-up of 40,304,078 person-years. Median age at diagnosis was 42.1 ± 9.4 years (range 17.4-62.6). On univariate analysis, female sex (p < 0.01) and height (p < 0.01) were associated with risk of meningioma. When the data were stratified by sex, height remained a significant factor only in men. Spline analysis of the male subjects showed that a height of 1.62 m was associated with a minimum disease risk and a height of 1.85+ meters, with a significant risk.

conclusionsThis large population study showed that sex and adolescent height in males (> 1.85 m) were associated with an increased risk of meningioma in adulthood.

Indexed as

Body HeightAdolescentAdultFemaleFollow-Up StudiesHumansIncidenceIsraelMaleMeningeal NeoplasmsMeningiomaMiddle AgedProspective StudiesRegistriesRisk AssessmentRisk FactorsAllergyAutoimmune diseaseHeightMeningiomaSex

Identifiers

PMID32819306
PMCPMC7441683
OpenAlexW3081202781

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.