Evidence map›Paper›PMID 32819304›Full record

Trial reportBMC cancer2020

The impact of high-intensity interval training exercise on breast cancer survivors: a pilot study to explore fitness, cardiac regulation and biomarkers of the stress systems.

Kellie Toohey, Kate Pumpa, Andrew McKune, Julie Cooke, Marijke Welvaert, Joseph Northey, Clare Quinlan, Stuart Semple

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06336070 (Postmenopausal Oncological Women Exercising for Recover Their Health. Associations and Changes in Metabolic Flexibility and Autonomic Control After Two Training Programs), which is not on this map. Cited by 46 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 6 pooled it
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06336070 narecruitingnot on this mapstarted 2024, after this paper: background citation

Postmenopausal Oncological Women Exercising for Recover Their Health. Associations and Changes in Metabolic Flexibility and Autonomic Control After Two Training Programs (Muscle Power vs Metabolic Power): the POWER Health Study

TypeinterventionalSponsorUniversity of ValenciaRan2024 to 2028Enrolled56ConditionsBreast Cancer Female, Cardiometabolic Syndrome, Metabolism Disorder, Lipid, Autonomic DysfunctionArmsHIIT program (8 weeks), MPI program (8 weeks)
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 6 syntheses or guidelines pooled it, 77 citations in OpenAlex.

  1. Cardiovascular training for fatigue in people with cancer.The Cochrane database of systematic reviews · 2025
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  8. The impact of multimodal high intensity exercise program comparing online and onsite interventions in breast cancer survivors: a randomized controlled trial.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Kellie TooheyResearch Institute for Sport and Exercise, University of Canberra, Canberra, 2601, Australia. kellie.toohey@canberra.edu.au.ORCID http://orcid.org/0000-0002-1776-6200
Kate PumpaResearch Institute for Sport and Exercise, University of Canberra, Canberra, 2601, Australia.
Andrew McKuneResearch Institute for Sport and Exercise, University of Canberra, Canberra, 2601, Australia.
Julie CookeResearch Institute for Sport and Exercise, University of Canberra, Canberra, 2601, Australia.
Marijke WelvaertResearch Institute for Sport and Exercise, University of Canberra, Canberra, 2601, Australia.
Joseph NortheyResearch Institute for Sport and Exercise, University of Canberra, Canberra, 2601, Australia.
Clare QuinlanResearch Institute for Sport and Exercise, University of Canberra, Canberra, 2601, Australia.
Stuart SempleResearch Institute for Sport and Exercise, University of Canberra, Canberra, 2601, Australia.
University of Canberra · AUAustralian National University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiovascular disease (CVD) remains the largest cause of death in breast cancer survivors. The aim of this study was to explore the impact of exercise intensity on aerobic fitness and autonomic cardiac regulation (heart rate variability (HRV)) and salivary biomarkers of the stress systems (HPA-axis, cortisol; sympathetic nervous system, α-amylase) and mucosal immunity (secretory(s)-IgA), markers of increased risk of CVD in breast cancer survivors.

methodsParticipants were randomly assigned to; 1) high intensity interval training (HIIT); 2) moderate-intensity, continuous aerobic training (CMIT); or 3) a wait-list control (CON) for a 12-week (36 session) stationary cycling intervention. Cardiorespiratory fitness (VO

resultsSeventeen participants were included in this study (62 ± 8 years, HIIT; n = 6, CMIT; n = 5, CON; n = 6). A significant improvement (p ≤ 0.05) was observed for VO

conclusionHigh intensity interval training improved cardiovascular fitness in breast cancer survivors and improved cardiac regulation, and sympathetic nervous system (stress) responses in some individuals. High-intensity interval training was safe and effective for breast cancer survivors to participate in with promising results as a time efficient intensity to improve physical health and stress, reducing CVD risk.

trial registrationThis pilot study was retrospectively registered through the Australian New Zealand Clinical Trials Registry (ANZCTR): ACTRN12620000684921 .

Indexed as

Agedalpha-AmylasesAustraliaBiomarkersBreast NeoplasmsCancer SurvivorsCardiorespiratory FitnessCardiovascular DiseasesExercise TherapyFemaleHigh-Intensity Interval TrainingHumansHydrocortisoneMiddle AgedPilot ProjectsSedentary Behavioralpha-AmylasesBiomarkersHydrocortisoneBiomarkersCancerExerciseHealthHigh-intensityImmune functionStress

Identifiers

PMID32819304
PMCPMC7441660
OpenAlexW3080308133

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.