ArticleBMC nephrology2020
Association among kidney function, frailty, and oral function in patients with chronic kidney disease: a cross-sectional study.
Article in BMC nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Association between oral hypofunction and general health: a systematic review.BMC oral health · 2023Pooled it
- Renal function and comprehensive frailty in community-dwelling older adults: cross-sectional and longitudinal analyses.Clinical and experimental nephrology · 2026Article
- Frailty, socioeconomic factors, and nutritional biomarkers in patients with nondialysis chronic kidney disease: A cross-sectional analysis.The Journal of international medical research · 2026Article
- Association of Oral Frailty with Physical Frailty and Malnutrition in Patients on Peritoneal Dialysis.Nutrients · 2025Article
- A Causal Association Study Between Chronic Kidney Disease and Oral Health: A Mendelian Randomization Study.Health science reports · 2025Article
- Association of Physiological Reserve Obtained from Cardiopulmonary Exercise Testing and Frailty with All-Cause Mortality in Patients on Hemodialysis.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- Oral Frailty as a Risk Factor for Fall Incidents among Community-Dwelling People.Geriatrics (Basel, Switzerland) · 2024Article
- Epidemiology and risk factors of oral frailty among older people: an observational study from China.BMC oral health · 2024Observational
- Association of the number of remaining teeth with kidney function in community-dwelling healthy older adults: a cross-sectional study.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2023Article
- Use of frailty assessment instruments in nephrology populations: a scoping review.BMC geriatrics · 2023Article
- Association between Bone Mineral Density and Oral Frailty on Renal Function: Findings from the Shika Study.Healthcare (Basel, Switzerland) · 2023Article
- Relationships between cystatin C and creatinine-based eGFR with low tongue pressure in Japanese rural community-dwelling older adults.Clinical and experimental dental research · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundChronic kidney disease (CKD) involves many factors that can cause frailty and oral hypofunction. We aimed to investigate the prevalence of frailty and oral hypofunction and to examine the associations among kidney function, frailty, and oral function in adults with CKD in Japan.
methodsThis cross-sectional study was conducted at two institutions. The participants included 109 patients with CKD stages 3-5 who visited outpatient clinics or were admitted for inpatient treatment. Frailty was evaluated using the Japanese version of the Cardiovascular Health Study frailty criteria. Oral function was evaluated by assessing oral motor skills [oral diadochokinesis (ODK) rate], masticatory ability, and the repetitive saliva swallowing test. The estimated glomerular filtration rate (eGFR) was used to indicate kidney function. We examined the associations among kidney function, frailty, and oral function using binomial logistic regression analysis.
resultsIn total, 31 participants (28.4%) were classified as being frail. Univariate analysis showed that age, body mass index, eGFR, and haemoglobin level were significantly associated with frailty. ODK and swallowing function were significantly associated with frailty. Multivariate analysis revealed that frailty was significantly associated with eGFR [odds ratio (OR) 0.96, 95% confidence interval (CI) 0.92-1.00, p = 0.048] and ODK rate (OR 0.68, CI 0.47-0.98, p = 0.038). However, no significant association was found between CKD severity and masticatory or swallowing function.
conclusionWe found a high prevalence of frailty in patients with CKD and a significant association between frailty and oral motor skills, affecting the swallowing function of patients with nondialysis CKD. The high prevalence of frailty among patients with CKD suggests that routine assessment of frailty is necessary to prevent the development of severe complications. In addition, oral and kidney function should be carefully evaluated, and oral health education and interventions should be performed for patients with CKD.
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