Evidence map›Paper›PMID 32818719›Full record

ArticleBrain and language2020

Lexical-semantic search related to side of onset and putamen volume in Parkinson's disease.

Daymond Wagner, Paul J Eslinger, Nicholas W Sterling, Guangwei Du, Eun-Young Lee, Martin Styner, Mechelle M Lewis, Xuemei Huang

Abstract read
In one paragraph

Article in Brain and language, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daymond WagnerDepartments of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, United States. Electronic address: dwagner1@pennstatehealth.psu.edu.
Paul J EslingerDepartments of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, United States; Departments of Neural and Behavioral Sciences, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, United States; Departments of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, United States. Electronic address: peslinger@pennstatehealth.psu.edu.
Nicholas W SterlingDepartments of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, United States. Electronic address: nicholas.william.sterling@emory.edu.
Guangwei DuDepartments of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, United States. Electronic address: guangweidu@pennstatehealth.psu.edu.
Eun-Young LeeDepartments of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, United States. Electronic address: elee@pennstatehealth.psu.edu.
Martin StynerDepartments of Psychiatry, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, United States; Departments of Computer Science, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, United States. Electronic address: styner@unc.edu.
Mechelle M LewisDepartments of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, United States; Departments of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, United States. Electronic address: mlewis5@pennstatehealth.psu.edu.
Xuemei HuangDepartments of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, United States; Departments of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, United States; Departments of Neurosurgery, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, United States; Departments of Kinesiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, United States. Electronic address: xhuang3@pennstatehealth.psu.edu.

Funding

Penn State Clinical and Translational Science InstituteUL1TR000127 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2012 to 2015
$17.1M
Regional Brain Manganese Accumulation and Functional Consequences in WeldersR01ES019672 · NIEHS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HUANG, XUEMEI · 2011 to 2021
$5.9M
Discovery of Multimodal Biomarkers for Parkinsonian Syndromes, Their Progression, and Pathological RelevanceU01NS112008 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HUANG, XUEMEI, KANTHASAMY, ANUMANTHA GOUNDER · 2019 to 2023
$5.5M
PENN STATE CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR033184 · NCRR · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2011 to 2011
$4.5M
Multimodal MRI Markers of Nigrostriatal Pathology in Parkinson's DiseaseU01NS082151 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HUANG, XUEMEI · 2012 to 2016
$4.2M
Structural MRI marker(s) of Parkinson's Disease's ProgressionR01NS060722 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HUANG, XUEMEI · 2009 to 2013
$2.9M
Penn State Clinical and Translational Science InstituteTL1TR000125 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2012 to 2015
$550k
NCATS NIH HHS TL1 TR000125NCATS NIH HHS UL1 TR000127NCRR NIH HHS UL1 RR033184NIEHS NIH HHS R01 ES019672NINDS NIH HHS R01 NS060722NINDS NIH HHS U01 NS082151NINDS NIH HHS U01 NS112008
6 · The paper itself

Abstract

Parkinson's disease (PD) is characterized by dopaminergic cell loss and reduced striatal volume. Prior studies have demonstrated striatal involvement in access to lexical-semantic knowledge and damage to this structure may be evident in the lexical properties of responses. Semantic fluency task responses from early stage, non-demented PD participants with right (PD-R) or left (PD-L) lateralizing symptoms were compared to matched controls on lexical properties (word frequency, age of acquisition) and correlated with striatal volumes segmented from T1-weighted brain MR images. PD-R participants produced semantic fluency responses of a lower age of acquisition than PD-L and control participants (p < 0.05). PD-R age of acquisition responses correlated positively with putamen volume (p < 0.05), while age of acquisition of responses correlated negatively with caudate volume in controls (p < 0.05). Findings provide evidence for a role of the striatum in lexical-semantic access and qualitative changes in lexical access in select PD patients.

Indexed as

SemanticsAgedAge FactorsCase-Control StudiesCorpus StriatumFemaleFunctional LateralityHumansLanguage DevelopmentLanguage DisordersMagnetic Resonance ImagingMaleMiddle AgedOrgan SizeParkinson DiseasePutamenBasal gangliaCognitionLexical accessMotor asymmetryMRIParkinson's diseaseStriatal volumeVoxel-based morphometry

Identifiers

PMID32818719
PMCPMC8189666

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.