Evidence map›Paper›PMID 32818613›Full record

ArticleNeuroImage2020

Variability and heritability of mouse brain structure: Microscopic MRI atlases and connectomes for diverse strains.

Nian Wang, Robert J Anderson, David G Ashbrook, Vivek Gopalakrishnan, Youngser Park, Carey E Priebe, Yi Qi, Rick Laoprasert, Joshua T Vogelstein, Robert W Williams and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Multiscale comparative connectomics.Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Merged magnetic resonance and light sheet microscopy of the whole mouse brain.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Incubation of palatable food craving is associated with brain-wide neuronal activation in mice.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nian WangDuke Center for In Vivo Microscopy, Department of Radiology, Duke University, Duke University Medical Center Box 3302, Durham, NC 27710, USA.
Robert J AndersonDuke Center for In Vivo Microscopy, Department of Radiology, Duke University, Duke University Medical Center Box 3302, Durham, NC 27710, USA.
David G AshbrookDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Vivek GopalakrishnanDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21287, USA.
Youngser ParkCenter for Imaging Science, Johns Hopkins University, Baltimore, MD 21287, USA.
Carey E PriebeCenter for Imaging Science, Johns Hopkins University, Baltimore, MD 21287, USA; Department of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, MD 21287, USA.
Yi QiDuke Center for In Vivo Microscopy, Department of Radiology, Duke University, Duke University Medical Center Box 3302, Durham, NC 27710, USA.
Rick LaoprasertDuke Center for In Vivo Microscopy, Department of Radiology, Duke University, Duke University Medical Center Box 3302, Durham, NC 27710, USA.
Joshua T VogelsteinDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21287, USA; Center for Imaging Science, Johns Hopkins University, Baltimore, MD 21287, USA; Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21287, USA; Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21287, USA.
Robert W WilliamsDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
G Allan JohnsonDuke Center for In Vivo Microscopy, Department of Radiology, Duke University, Duke University Medical Center Box 3302, Durham, NC 27710, USA; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA. Electronic address: gjohnson@duke.edu.

Funding

INTEGRATED CENTER FOR IN VIVO MICROSCOPYP41EB015897 · NIBIB · DUKE UNIVERSITY · PI JOHNSON, GEORGE ALLAN · 2012 to 2017
$7.4M
A Unified High Performance Web Service for Systems Genetics and Precision MedicineR01GM123489 · NIGMS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI PRINS, PJOTR, SEN, SAUNAK · 2017 to 2024
$3.7M
Translational Systems Genetics of Mitochondria, Metabolism, and AgingR01AG043930 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WILLIAMS, ROBERT W. · 2013 to 2017
$2.5M
Waxholm Space for Rodent NeuroinformaticsR01NS096720 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI GEE, JAMES C · 2016 to 2019
$2.4M
Agilent Direct Drive 9.4T MRS/MRI ConsoleS10OD010683 · OD · DUKE UNIVERSITY · PI JOHNSON, GEORGE ALLAN · 2012 to 2012
$597k
NIA NIH HHS R01 AG043930NIBIB NIH HHS P41 EB015897NIGMS NIH HHS R01 GM123489NIH HHS S10 OD010683NINDS NIH HHS R01 NS096720
6 · The paper itself

Abstract

Genome-wide association studies have demonstrated significant links between human brain structure and common DNA variants. Similar studies with rodents have been challenging because of smaller brain volumes. Using high field MRI (9.4 T) and compressed sensing, we have achieved microscopic resolution and sufficiently high throughput for rodent population studies. We generated whole brain structural MRI and diffusion connectomes for four diverse isogenic lines of mice (C57BL/6J, DBA/2J, CAST/EiJ, and BTBR) at spatial resolution 20,000 times higher than human connectomes. We measured narrow sense heritability (h

Indexed as

Brain MappingDiffusion Tensor ImagingAnimalsBrainConnectomeDiffusion Magnetic Resonance ImagingGenome-Wide Association StudyMagnetic Resonance ImagingMiceConnectomeMouse brainMRI/DTIMR microscopy

Identifiers

PMID32818613
PMCPMC8442986

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.