Evidence map›Paper›PMID 32818434›Full record

ReviewThe Lancet. Infectious diseases2020

COVID-19 and multisystem inflammatory syndrome in children and adolescents.

Li Jiang, Kun Tang, Mike Levin, Omar Irfan, Shaun K Morris, Karen Wilson, Jonathan D Klein, Zulfiqar A Bhutta

Erratum issuedOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Lancet. Infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 401 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
401citing papers in PubMed, 9 pooled it
148.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

401 citing papers in PubMed, 9 syntheses or guidelines pooled it, 824 citations in OpenAlex.

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341 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 5 countries.

Li JiangCentre for Global Child Health, The Hospital for Sick Children, Toronto, ON, Canada.
Kun TangCentre for Global Child Health, The Hospital for Sick Children, Toronto, ON, Canada; Vanke School of Public Health, Tsinghua University, Beijing, China.
Mike LevinDepartment of Infectious Disease, Imperial College London, London, UK.
Omar IrfanCentre for Global Child Health, The Hospital for Sick Children, Toronto, ON, Canada.
Shaun K MorrisCentre for Global Child Health, The Hospital for Sick Children, Toronto, ON, Canada; Division of Infectious Diseases, The Hospital for Sick Children, Toronto, ON, Canada.
Karen WilsonMount Sinai Kravis Children's Hospital, New York, NY, USA.
Jonathan D KleinDepartment of Pediatrics, University of Illinois at Chicago, Chicago, IL, USA.
Zulfiqar A BhuttaCentre for Global Child Health, The Hospital for Sick Children, Toronto, ON, Canada; Institute for Global Health and Development, Aga Khan University, Karachi, Pakistan. Electronic address: zulfiqar.bhutta@aku.edu.
Hospital for Sick Children · CAAga Khan University · PKImperial College London · GBTsinghua University · CNUniversity of Illinois Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As severe acute respiratory syndrome coronavirus 2 continues to spread worldwide, there have been increasing reports from Europe, North America, Asia, and Latin America describing children and adolescents with COVID-19-associated multisystem inflammatory conditions. However, the association between multisystem inflammatory syndrome in children and COVID-19 is still unknown. We review the epidemiology, causes, clinical features, and current treatment protocols for multisystem inflammatory syndrome in children and adolescents associated with COVID-19. We also discuss the possible underlying pathophysiological mechanisms for COVID-19-induced inflammatory processes, which can lead to organ damage in paediatric patients who are severely ill. These insights provide evidence for the need to develop a clear case definition and treatment protocol for this new condition and also shed light on future therapeutic interventions and the potential for vaccine development. TRANSLATIONS: For the French, Chinese, Arabic, Spanish and Russian translations of the abstract see Supplementary Materials section.

Indexed as

BetacoronavirusAdolescentAnti-Inflammatory Agents, Non-SteroidalAntiviral AgentsChildChild, PreschoolCoronavirus InfectionsCOVID-19COVID-19 Drug TreatmentFemaleHumansImmunoglobulins, IntravenousInfantInfant, NewbornMaleMucocutaneous Lymph Node SyndromeAnti-Inflammatory Agents, Non-SteroidalAntiviral AgentsImmunoglobulins, Intravenous

Identifiers

PMID32818434
PMCPMC7431129
OpenAlexW3049087060

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.