ArticleMolecular cell2020
Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound β
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Article in Molecular cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
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Who cites it
45 citing papers in PubMed, 86 citations in OpenAlex.
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- The Role and Mechanisms of G protein-coupled receptors in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- Exercise-regulated lipolysis: Its role and mechanism in health and diseases.Journal of advanced research · 2025Review
- Pericarpium Trichosanthis Injection Protects Isoproterenol-Induced Acute Myocardial Ischemia via Suppressing Inflammatory Damage and Apoptosis Pathways.Biomolecules · 2025Article
- How Ligands Achieve Biased Signaling toward Arrestins.Biochemistry · 2025Review
- Altered O-glycosylation of βThe FEBS journal · 2025Article
- Architecture and activation of single-pass transmembrane receptor guanylyl cyclase.Nature structural & molecular biology · 2025Article
- Molecular simulations reveal intricate coupling between agonist-bound β-adrenergic receptors and G protein.iScience · 2025Article
- Distinct binding conformations of epinephrine with α- and β-adrenergic receptors.Experimental & molecular medicine · 2024Article
- Optical control of cell-surface and endomembrane-exclusive β-adrenergic receptor signaling.The Journal of biological chemistry · 2024Article
- G Protein-Coupled Receptor-Ligand Pose and Functional Class Prediction.International journal of molecular sciences · 2024Article
- Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Cryo-electron microscopy for GPCR research and drug discovery in endocrinology and metabolism.Nature reviews. Endocrinology · 2024Review
- Optical Control of Cell-Surface and Endomembrane-Exclusive β-Adrenergic Receptor Signaling.bioRxiv : the preprint server for biology · 2024Article
- Binding kinetics drive G protein subtype selectivity at the βNature communications · 2024Article
- A cholesterol switch controls phospholipid scrambling by G protein-coupled receptors.The Journal of biological chemistry · 2024Article
- ChemEM: Flexible Docking of Small Molecules in Cryo-EM Structures.Journal of medicinal chemistry · 2024Article
- Structures of Adrenoceptors.Handbook of experimental pharmacology · 2024Review
- Signalling of Adrenoceptors: Canonical Pathways and New Paradigms.Handbook of experimental pharmacology · 2024Review
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Authors and funding
16 authors at 6 institutions in 2 countries.
Minfei SuDepartment of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA.
Lan ZhuSchool of Molecular Sciences and Biodesign Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
Yixiao ZhangLaboratory of Molecular Electron Microscopy, The Rockefeller University, New York, NY 10065, USA.
Navid PaknejadStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Raja DeyDepartment of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA.
Jianyun HuangDepartment of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA.
Ming-Yue LeeSchool of Molecular Sciences and Biodesign Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
Dewight WilliamsJohn M. Cowley Center for High Resolution Electron Microscopy, Arizona State University, Tempe, AZ 85287, USA.
Kelsey D JordanSimons Electron Microscopy Center, New York Structural Biology Center, New York, NY 10027, USA.
Edward T EngSimons Electron Microscopy Center, New York Structural Biology Center, New York, NY 10027, USA.
Oliver P ErnstDepartment of Biochemistry and Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
Joel R MeyersonDepartment of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA.
Richard K HiteStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Thomas WalzLaboratory of Molecular Electron Microscopy, The Rockefeller University, New York, NY 10065, USA.
Wei LiuSchool of Molecular Sciences and Biodesign Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA. Electronic address: w.liu@asu.edu.
Xin-Yun HuangDepartment of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA. Electronic address: xyhuang@med.cornell.edu.
Cornell University · USArizona State University · USMemorial Sloan Kettering Cancer Center · USNew York Structural Biology Center · USRockefeller University · USUniversity of Toronto · CA
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MZWITTERION SURFACTANT DDMAB FOR IMPROV STABIL OF PROTEINP41RR001209 · NCRR · STANFORD UNIVERSITY · PI SCOTT, EMILY E · 1985 to 2011
$38.9MTRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2012 to 2021
$14.7MMolecular characterization of the multi-modal regulation of inositol 1,4,5-trisphosphate receptorsR01GM132307 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI HITE, RICHARD KEVIN · 2019 to 2023
$2.0MFunctions of G-proteins in Endothelial CellsR01HL130478 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI HUANG, XIN-YUN · 2016 to 2019
$1.7MStructure Determination of G Protein-Coupled Receptors by Microcrystal Electron DiffractionR01GM124152 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI NANNENGA, BRENT · 2017 to 2021
$1.6MMolecular Basis of B1-Adrenergic Receptor FunctionR01GM138676 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HUANG, XIN-YUN · 2020 to 2023
$1.5MStructure and Function of Dopamine ReceptorsR21DA042298 · NIDA · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI LIU, WEI · 2017 to 2018
$404kMolecular Mechanisms of Apoptosis Regulation Through IP3 ReceptorsF31CA243235 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI PAKNEJAD , NAVID · 2019 to 2022
$179kCIHR 159464NCI NIH HHS F31 CA243235NCI NIH HHS P30 CA008748NCRR NIH HHS P41 RR001209NHLBI NIH HHS R01 HL130478NIDA NIH HHS R21 DA042298NIGMS NIH HHS P41 GM103310NIGMS NIH HHS R01 GM124152NIGMS NIH HHS R01 GM132307NIGMS NIH HHS R01 GM138676
Abstract
Cardiac disease remains the leading cause of morbidity and mortality worldwide. The β
Indexed as
AnimalsBinding SitesCattleCell LineGTP-Binding Protein alpha Subunits, GsGuanosine DiphosphateGuanosine TriphosphateIsoproterenolModels, MolecularProtein BindingProtein DomainsProtein Structure, SecondaryReceptors, Adrenergic, beta-1GTP-Binding Protein alpha Subunits, GsGuanosine DiphosphateGuanosine TriphosphateIsoproterenolReceptors, Adrenergic, beta-1activation of G-proteinscardiac diseasecryo-electron microscopyG-proteinG-protein-coupled receptorsignal transductionstructural biologyβ1-adrenergic receptor
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