ArticleNeurosurgery2020
Long-Term Disease Burden and Survivorship Issues After Surgery and Radiotherapy of Intracranial Meningioma Patients.
Article in Neurosurgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Health-related quality-of-life outcomes in CNS WHO grade 2 and 3 meningioma: a systematic review.Neurosurgical review · 2025Pooled it
- Single session versus multisession stereotactic radiosurgery for the management of intracranial meningiomas: a systematic review and meta-analysis.Journal of neuro-oncology · 2023Pooled it
- A multidisciplinary program for meningioma treatment, research, and support services.Neuro-oncology practice · 2026Article
- Validation of the EORTC QLQ-C30 and QLQ-BN20, including WHO performance status interrater reliability, for evaluation of patients with intracranial meningiomas.Neuro-oncology practice · 2025Article
- Neurocognitive evaluation in patients with intracranial Meningiomas: A systematic review.Brain & spine · 2025Review
- Long-term neurocognitive and psychological outcomes in meningioma survivors: Individual changes over time and radiation dosimetry.Neuro-oncology practice · 2024Article
- Identification of health-related quality of life profiles among long-term survivors of primary central nervous system tumors.Journal of neuro-oncology · 2023Article
- Review
- The management of incidental meningioma: An unresolved clinical conundrum.Neuro-oncology advances · 2023Article
- Healthcare utilization and costs among intracranial meningioma patients during long-term follow-up.Journal of neuro-oncology · 2023Article
- Quality of life outcomes in incidental and operated meningiomas (QUALMS): a cross-sectional cohort study.Journal of neuro-oncology · 2023Article
- An economic study of neuro-oncological patients in a large developing country: a cost analysis.Arquivos de neuro-psiquiatria · 2022Article
- Incidence trends and survival analysis of atypical meningiomas: a population-based study from 2004 to 2018.Journal of neuro-oncology · 2022Article
- Long-term neurocognitive, psychological, and return to work outcomes in meningioma patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Determinants and predictors for the long-term disease burden of intracranial meningioma patients.Journal of neuro-oncology · 2021Article
- Long-term health-related quality of life in meningioma survivors: A mixed-methods systematic review.Neuro-oncology advancesArticle
- The long-term caregiver burden in World Health Organization grade I and II meningioma: It is not just the patient.Neuro-oncology advancesArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany intracranial meningioma patients have an impaired health-related quality of life (HRQoL) and neurocognitive functioning up to 4 yr after intervention.
objectiveTo assess the long-term (≥5 yr) disease burden of meningioma patients.
methodsIn this multicenter cross-sectional study, patients ≥5 yr after intervention (including active magnetic resonance imaging (MRI) surveillance) were included and assessed for HRQoL (Short-Form Health Survey 36), neurocognitive functioning (neuropsychological assessment), anxiety and depression (Hospital Anxiety and Depression Scale), and work productivity (Short Form-Health and Labour Questionnaire). Multivariable and propensity score regression analyses were used to compare patients and controls, and different treatment strategies corrected for possible confounders. Clinically relevant differences were reported.
resultsAt a median of 9 yr follow-up after intervention, meningioma patients (n = 190) reported more limitations due to physical (difference 12.5 points, P = .008) and emotional (13.3 points, P = .002) health problems compared with controls. Patients also had an increased risk to suffer from anxiety (odds ratio [OR]: 2.6, 95% CI: 1.2-5.7) and depression (OR: 3.7, 95% CI: 1.3-10.5). Neurocognitive deficits were found in 43% of patients. Although postoperative complications, radiotherapy, and reresection were associated with worse verbal memory, attention, and executive functioning when compared to patients resected once, the only clinically relevant association was between reresection and worse attention (-2.11, 95% CI: -3.52 to -0.07). Patients of working age less often had a paid job (48%) compared with the working-age Dutch population (72%) and reported more obstacles at work compared with controls.
conclusionIn the long term, a large proportion of meningioma patients have impaired HRQoL, neurocognitive deficits, and high levels of anxiety or depression. Patients treated with 1 resection have the best neurocognitive functioning.
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