ArticleThe Journal of clinical endocrinology and metabolism2020
Risk of Adverse Clinical Outcomes in Hyponatremic Adult Patients Hospitalized for Acute Medical Conditions: A Population-Based Cohort Study.
Article in The Journal of clinical endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- ENDOCRINOLOGY IN THE TIME OF COVID-19-2021 UPDATES: The management of diabetes insipidus and hyponatraemia.European journal of endocrinology · 2021Guideline
- Impact of Nephrology Consultation on Moderate and Severe Hyponatremia Outcomes and Length of Hospital Stay.Cureus · 2025Article
- Safety and Efficacy of Salt Restriction Across the Spectrum of Heart Failure.Journal of cardiovascular development and disease · 2025Review
- Effect of spironolactone on cardiovascular and renal outcomes in patients with chronic kidney disease.Clinical kidney journal · 2025Article
- Characteristics, management and outcomes of patients with hyponatraemia presenting to an Irish tertiary hospital.Endocrine connections · 2025Article
- The Association of Outdoor Temperature with Severe Hyponatremia.Journal of the American Society of Nephrology : JASN · 2025Article
- Relationship of severity of hyponatremia and adverse outcomes in children visiting the emergency department.Frontiers in pediatrics · 2024Article
- Associations between Baseline Hyponatremia and Activities of Daily Living and Muscle Health in Convalescent Stroke Patients.Progress in rehabilitation medicine · 2024Article
- Pancreatic steatosis and metabolic pancreatic disease: a new entity?Internal and emergency medicine · 2023Review
- Syndrome of Inappropriate Antidiuresis: From Pathophysiology to Management.Endocrine reviews · 2023Review
- Hyponatremia Demystified: Integrating Physiology to Shape Clinical Practice.Advances in kidney disease and health · 2023Review
- Approach to the Patient: Hyponatremia and the Syndrome of Inappropriate Antidiuresis (SIAD).The Journal of clinical endocrinology and metabolism · 2022Review
- Hyponatraemia and the syndrome of inappropriate antidiuresis (SIAD) in cancer.Endocrine oncology (Bristol, England) · 2022Review
- The management of acute and chronic hyponatraemia.Therapeutic advances in endocrinology and metabolism · 2022Review
- Sodium alterations impair the prognosis of hospitalized patients with COVID-19 pneumonia.Endocrine connections · 2021Article
- Efficacy and Safety of Isotonic and Hypotonic Intravenous Maintenance Fluids in Hospitalised Children: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.Children (Basel, Switzerland) · 2021Article
- Dysnatremia is a Predictor for Morbidity and Mortality in Hospitalized Patients with COVID-19.The Journal of clinical endocrinology and metabolism · 2021Article
- Hyponatremia Intervention Trial (HIT): Study Protocol of a Randomized, Controlled, Parallel-Group Trial With Blinded Outcome Assessment.Frontiers in medicine · 2021Article
- Management and Clinical Outcome of Posterior Reversible Encephalopathy Syndrome in Pediatric Oncologic/Hematologic Diseases: A PRES Subgroup Analysis With a Large Sample Size.Frontiers in pediatrics · 2021Article
- Treatment of Refractory Syndrome of Inappropriate Antidiuresis With Sodium-Glucose Cotransporter-2 Inhibitor.AACE endocrinology and diabetesArticle
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextHyponatremia has been associated with excess long-term morbidity and mortality. However, effects during hospitalization are poorly studied.
objectiveThe objective of this work is to examine the association of hyponatremia with the risk of in-hospital mortality, 30-day readmission, and other short-term adverse events among medical inpatients. DESIGN AND
settingA population-based cohort study was conducted using a Swiss claims database of medical inpatients from January 2012 to December 2017. PATIENTS: Hyponatremic patients were 1:1 propensity-score matched with normonatremic medical inpatients.
main outcome measureThe primary outcome was a composite of all-cause in-hospital mortality and 30-day hospital readmission. Secondary outcomes were intensive care unit (ICU) admission, intubation rate, length-of-hospital stay (LOS), and patient disposition after discharge.
resultsAfter matching, 94 352 patients were included in the cohort. Among 47 176 patients with hyponatremia, 8383 (17.8%) reached the primary outcome compared with 7994 (17.0%) in the matched control group (odds ratio [OR] 1.06 [95% CI, 1.02-1.10], P = .001). Hyponatremic patients were more likely to be admitted to the ICU (OR 1.43 [95% CI, 1.37-1.50], P < .001), faced a 56% increase in prolonged LOS (95% CI, 1.52-1.60, P < .001), and were admitted more often to a postacute care facility (OR 1.38 [95% CI 1.34-1.42, P < .001). Of note, patients with the syndrome of inappropriate antidiuresis (SIAD) had lower in-hospital mortality (OR 0.67 [95% CI, 0.56-0.80], P < .001) as compared with matched normonatremic controls.
conclusionIn this study, hyponatremia was associated with increased risk of short-term adverse events, primarily driven by higher readmission rates, which was consistent among all outcomes except for decreased in-hospital mortality in SIAD patients.
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