ArticleStructural dynamics (Melville, N.Y.)2020
Perspectives on single particle imaging with x rays at the advent of high repetition rate x-ray free electron laser sources.
Article in Structural dynamics (Melville, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Model-free pattern separation of two-color ultrafast X-ray diffraction.Nature communications · 2026Article
- Impact of gas background on XFEL single-particle imaging.Scientific reports · 2025Article
- Coaxial helium electrospray for single-particle imaging at X-ray free electron lasers.Journal of synchrotron radiation · 2025Article
- Structural biology in the age of X-ray free-electron lasers and exascale computing.Current opinion in structural biology · 2024Review
- Computational study of diffraction image formation from XFEL irradiated single ribosome molecule.Scientific reports · 2024Article
- A workflow for single-particle structure determination via iterative phasing of rotational invariants in fluctuation X-ray scattering.Journal of applied crystallography · 2024Article
- Enhancing electrospray ionization efficiency for particle transmission through an aerodynamic lens stack.Journal of synchrotron radiation · 2024Article
- Helium-electrospray improves sample delivery in X-ray single-particle imaging experiments.Scientific reports · 2024Article
- Characterization of Biological Samples Using Ultra-Short and Ultra-Bright XFEL Pulses.Advances in experimental medicine and biology · 2024Article
- A phenomenological model of the X-ray pulse statistics of a high-repetition-rate X-ray free-electron laser.IUCrJ · 2023Article
- SARS-CoV-2 proteins structural studies using synchrotron radiation.Biophysical reviews · 2023Review
- Water layer and radiation damage effects on the orientation recovery of proteins in single-particle imaging at an X-ray free-electron laser.Scientific reports · 2023Article
- Multiple-core-hole resonance spectroscopy with ultraintense X-ray pulses.Nature communications · 2023Article
- Coherent diffractive imaging of proteins and viral capsids: simulating MS SPIDOC.Analytical and bioanalytical chemistry · 2023Article
- Expected resolution limits of x-ray free-electron laser single-particle imaging for realistic source and detector properties.Structural dynamics (Melville, N.Y.) · 2022Article
- Article
- Shot-to-shot two-dimensional photon intensity diagnostics within megahertz pulse-trains at the European XFEL.Journal of synchrotron radiation · 2022Article
- Tree-Code Based Improvement of Computational Performance of the X-ray-Matter-Interaction Simulation Tool XMDYN.Molecules (Basel, Switzerland) · 2022Article
- 3D printed devices and infrastructure for liquid sample delivery at the European XFEL.Journal of synchrotron radiation · 2022Article
- Optimizing the geometry of aerodynamic lens injectors for single-particle coherent diffractive imaging of gold nanoparticles.Journal of applied crystallography · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
X-ray free electron lasers (XFELs) now routinely produce millijoule level pulses of x-ray photons with tens of femtoseconds duration. Such x-ray intensities gave rise to the idea that weakly scattering particles-perhaps single biomolecules or viruses-could be investigated free of radiation damage. Here, we examine elements from the past decade of so-called single particle imaging with hard XFELs. We look at the progress made to date and identify some future possible directions for the field. In particular, we summarize the presently achieved resolutions as well as identifying the bottlenecks and enabling technologies to future resolution improvement, which in turn enables application to samples of scientific interest.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.