Evidence map›Paper›PMID 32818136›Full record

ArticleOpen forum infectious diseases2020

Effects of Prior Influenza Exposure on Immunogenicity of Influenza Vaccine.

Jia-Qian Cao, Peng-Fei Jin, Jing-Xin Li, Zhao-Zhun Zeng, Li Zhang, Fan-Yue Meng, Kai Chu, Yuan-Yuan Wang, Feng-Cai Zhu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jia-Qian CaoSchool of Public Health, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
Peng-Fei JinVaccine Clinical Evaluation Department, Jiangsu Province Center for Disease Control and Prevention, Nanjing, Jiangsu, People's Republic of China.
Jing-Xin LiVaccine Clinical Evaluation Department, Jiangsu Province Center for Disease Control and Prevention, Nanjing, Jiangsu, People's Republic of China.
Zhao-Zhun ZengSchool of Public Health, Southeast University, Nanjing, Jiangsu, People's Republic of China.
Li ZhangVaccine Clinical Evaluation Department, Jiangsu Province Center for Disease Control and Prevention, Nanjing, Jiangsu, People's Republic of China.
Fan-Yue MengVaccine Clinical Evaluation Department, Jiangsu Province Center for Disease Control and Prevention, Nanjing, Jiangsu, People's Republic of China.
Kai ChuVaccine Clinical Evaluation Department, Jiangsu Province Center for Disease Control and Prevention, Nanjing, Jiangsu, People's Republic of China.
Yuan-Yuan WangSchool of Public Health, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
Feng-Cai ZhuSchool of Public Health, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
Jiangsu Provincial Center for Disease Control and Prevention · CNNanjing Medical University · CNSoutheast University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn this study, we investigated the effects of prior influenza exposure on vaccine-elicited humor immune responses to circulating influenza variants.

methodWe randomly selected 360 participants in previous clinical trials stratified by age. Blood samples were collected and tested by hemagglutination-inhibition tests during the 2015-2016 influenza seasons in China. The antigenic map was plotted and antigenic distance was calculated.

resultsSubjects with H1-priming had higher cross-reactive antibodies titers against A/JiangsuTinghu/11019/2015(H3N2) compared with subjects with B-priming did (

conclusionsOur results suggest that prior exposure to H1 or B influenza virus may influence cross-reactivity of H3-specific postvaccination responses and consequently could influence the vaccine effectiveness. Our findings also support that there are age-specific differences in human postvaccination responses.

Indexed as

cross-reactivityseasonal influenzavaccine

Identifiers

PMID32818136
PMCPMC7423295
OpenAlexW3032641896

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.